| 引用本文： |
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郑琦,邹子鸿,蔡佳,简纪常.鱼类免疫因子Prx 1和Prx 2的研究进展[J].广西科学院学报,2019,35(3):172-175,184. [点击复制]
- ZHENG Qi,ZOU Zihong,CAI Jia,JIAN Jichang.Advance in Peroxiredoxin 1 and Peroxiredoxin 2 of Teleost Immune Factors[J].Journal of Guangxi Academy of Sciences,2019,35(3):172-175,184. [点击复制]
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| 摘要: |
| Peroxiredoxin 1（Prx 1）和Peroxiredoxin 2（Prx 2）是脊椎动物中一种保守的免疫因子，在鱼类的非特异性免疫中扮演重要角色，也叫作自然杀伤增强因子（Natural killer enhancing factor，NKEF A/B）。两类蛋白的N端和C端各含有一个活性半胱氨酸位点。Prx 1和Prx 2能清除机体活性氧（ROS）如H2O2，同时还参与鱼体的抗病免疫。本文对鱼类Prx 1和Prx 2的结构、抗氧化机制、生物学功能进行综述性介绍。 |
| 关键词: 鱼类 免疫因子 Prx 1 Prx 2 抗氧化蛋白 结构 功能 |
| DOI：10.13657/j.cnki.gxkxyxb.20190905.004 |
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| 基金项目:国家自然科学基金项目（31302226，31572651）和广东海洋大学优秀硕士学位论文培育项目（201833）资助。 |
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| Advance in Peroxiredoxin 1 and Peroxiredoxin 2 of Teleost Immune Factors |
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ZHENG Qi, ZOU Zihong, CAI Jia, JIAN Jichang
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| (College of Fishery, Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China) |
| Abstract: |
| Peroxiredoxin 1 (Prx 1) and Peroxiredoxin 2 (Prx 2) are conserved immune factors in vertebrates and play an important role in teleost innate immunity,which are also known as Natural Killer Enhancing Factor (NKEF A/B).Both types of proteins contain an active cysteine site at the N-terminus and C-terminus,respectively.Prx 1 and Prx 2 can eliminate reactive oxygen species (ROS) such as H2O2 and also participate in anti-pathogeny immune responses.In this paper,the structure,antioxidant mechanism and biological function of fish Prx 1 and Prx 2 were reviewed. |
| Key words: fish teleost peroxiredoxin 1 peroxiredoxin 2 immunity structure function |
