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杨建香,邱声祥,佘志刚,林永成.南海红树林内生真菌Gx-3a代谢产物研究[J].广西科学,2013,20(2):168-170. [点击复制]
- YANG Jian-xiang,QIU Sheng-xiang,SHE Zhi-gang,LIN Yong-cheng.Metabolites of Mangrove Endophytic Fungus Gx-3a from the South China Sea[J].Guangxi Sciences,2013,20(2):168-170. [点击复制]
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| 南海红树林内生真菌Gx-3a代谢产物研究 |
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杨建香1,2, 邱声祥1, 佘志刚3, 林永成3
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| (1.桂林师范高等专科学校, 广西桂林 541001;2.中国科学院华南植物园植物资源保护与可持续利用重点实验室, 广东广州 510650;3.中山大学化学与化学工程学院, 广东广州 510275) |
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| 摘要: |
| 采用反复硅胶柱色谱法和Sephadex LH-20凝胶色谱法分离纯化南海红树林内生真菌Gx-3a的代谢产物,并通过理化常数测定和光谱分析鉴定其化学结构。结果从南海红树林内生真菌Gx-3a的菌体中分离得到4个代谢产物:ditryptophenaline(1),3-hydroxy-4-(2,6,6-trimethyl-tetrahydro-2H-pyran-2-yl)benzoic acid(2),(E)-4,5-dihydroxy-3-(prop-1-enyl)cyclopent-2-enone(3),3,6-di-sec-butyl-1,4-dihy Droxypiperazine-2,5-dione(4),化合物1对口腔癌细胞KB,KBv200的抗肿瘤活性值分别为8.0和12.0 μmol/ml。4个化合物均首次从南海红树林内生真菌Gx-3a中分离得到。 |
| 关键词: 代谢产物 内生真菌 红树林 |
| DOI： |
| 投稿时间：2013-01-26修订日期：2013-03-27 |
| 基金项目:国家自然科学基金项目(30973635),中国科学院知识创新工程重要方向项目(KSCX2-YW-R-217),广西教育厅科研项目(201204LX497)资助。 |
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| Metabolites of Mangrove Endophytic Fungus Gx-3a from the South China Sea |
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YANG Jian-xiang1,2, QIU Sheng-xiang1, SHE Zhi-gang3, LIN Yong-cheng3
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| (1.Department of Chemistry and Engineering, Guilin Normal College, Guilin, Guangxi, 541001, China;2.Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, Guangdong, 510650, China;3.School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, Guangdong, 510275, China) |
| Abstract: |
| Secondary metabolites were studied from mangrove endophytic fungus No·Gx-3a in the south china sea.The compounds were isolated by column chromatography,and identified on the basia of physic-chemical constants, and spectral analysis.Four metabolites were obtained and elucidated as ditryptophenaline(1),3-hydroxy-4-(2,6,6-trimethyl-tetrahydro-2H-pyran-2-yl)benzoic acid(2),(E)-4,5-dihydroxy-3-(prop-1-enyl)cyclopent-2-enone(3),3,6-di-sec-butyl-1,4-dihydroxypiperazine-2,5-dione(4).In the preliminary bioassay, ditryptophenaline showes strong inhibittory activity on the KB,KBv200 with LD50 values of 8.0μMol and 12.0μMol,respectively.The four metabolites were obtained from endophytic fungus No·Gx-3a for the first time. |
| Key words: metabolites endophytic fungus mangrove |
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