| 引用本文： |
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刘永明,路影.解偶联蛋白-1基因3826A→G变异与2-型糖尿病的相关研究[J].广西科学,2000,7(2):125-127. [点击复制]
- Liu Yongming,Lu Ying.Relationship between the -3826 A→G Variation of Uncoupling Protein-1 Gene and Type-2 Diabetes Mellitus[J].Guangxi Sciences,2000,7(2):125-127. [点击复制]
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| 摘要: |
| 为研究解偶联蛋白-1(UCP-1)基因-3826 A→G变异与2-型糖尿病发生和发展的关系,应用聚合酶链反应限制性片段长度多态性(PCR-RFLP)方法检测了83例2-型糖尿病患者及74例正常对照者的UCP-1基因3826 A→G变异,并测定体质量指数(BMI)、空腹血糖血脂及胰岛素。结果:UCP-1基因-3826变异基因型频率与糖尿病无相关性;糖尿病组突变等位基因(G)与BMI呈正相关(P<0.05);糖尿病组中,G等位基因携带个体的低密度脂蛋白胆固醇(LDL-C)水平增高和高密度脂蛋白胆固醇(HDL-C)水平降低有显著意义(P值分别小于0.01和0.05)。表明UCP-1基因-3826 A→G变异与2-型糖尿病患者体脂增多相关;G等位基因可能是2-型糖尿病合并冠心病的一个危险因子。 |
| 关键词: 解偶联蛋白-1 基因 2-型糖尿病 |
| DOI： |
| 投稿时间：2000-03-13 |
| 基金项目:桂林医学院人才工程基金和奥地利Salzburg医学研究基金资助。 |
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| Relationship between the -3826 A→G Variation of Uncoupling Protein-1 Gene and Type-2 Diabetes Mellitus |
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Liu Yongming, Lu Ying
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| (Dept. of Biochemistry & Molecular Biology, Guilin Medical College, 20 Lequnlu, Guilin, Guangxi, 541001, China) |
| Abstract: |
| To investigate the role of the -3826 A→G variation of uncoupling protein-1 (UCP-1) gene in the genesis and development of type-2 diabetes mellitus, UCP-1 gene -3826 A→G variation was genotyped by PCR-RFLP assay in 83 type-2 diabetic subjects and 74 cases of normal control. And body mass index (BMI) as well as the levels of fasting plasma glucose, lipid profile and insulin were measured. Results:genotype frequencies of UCP-1 gene-3826 A to G variation were not associated with diabetes;mutant allele (G) was significant associated with BMI(P<0.05) in diabetic subgroups;the levels of low density lipoprotein cholesterol (LDL-C) were higher while the levels of high density lipoprotein cholesterol (HDL-C) were lower in patients with G allele than those without the G allele in diabetic subgroups (P<0.01 and P<0.05 respectively). These findings suggest that the -3826 A to G variation in UCP-1 gene contributes to increase body fat and the G allele tends to increase the risk of coronary heart disease in type-2 diabetic subjects. |
| Key words: uncoupling protein-1 gene type-2 diabetes mellitus |
