| 引用本文： |
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徐静,梅铭惠.细胞间粘附分子-1测定在肝细胞肝癌诊治中的意义[J].广西科学,1997,4(4):312-315. [点击复制]
- Xu Jing,Mei Minghui.Diagnostic and Therapeutic Significances of Detecting of Intercellular Adhesion Molecule-1 in Hepatocellular Carcinoma[J].Guangxi Sciences,1997,4(4):312-315. [点击复制]
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| 摘要: |
| 近年关于细胞间粘附分子-1(ICAM-1)与肝细胞肝癌(HCC)的研究表明,80%~96% HCC组织中ICAM-1的表达呈阳性,而血清中ICAM-1与组织ICAM-1的表达吻合率为87%;体外实验证实血清ICAM-1来源于肿瘤细胞表面脱落的ICAM-1;由于血清ICAM-1来源及结构的特点,可干扰机体免疫系统对肿瘤的监控,使病情迅速发展;临床上观察到血清ICAM-1水平与HCC病情的恶化程度成正比。上述研究结果提示:测定血清I-CAM-1水平,有可能成为HCC早期诊断的血清标记物;血清ICAM-1水平可作为HCC预后和疗效判断的指标,对提高HCC诊治水平具有重要意义。 |
| 关键词: 细胞间粘附分子 肝细胞肝癌 |
| DOI： |
| 投稿时间：1997-05-27 |
| 基金项目: |
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| Diagnostic and Therapeutic Significances of Detecting of Intercellular Adhesion Molecule-1 in Hepatocellular Carcinoma |
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Xu Jing, Mei Minghui
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| (Department of Hepato-Biliary Surgery, Guilin Medical College 56 Lequnlu, Guilin, 541001) |
| Abstract: |
| The studies on the relationship between intercellular adhesion molecule-1(ICAM-1) and hepatocellular carcinoma (HCC) have recently been shown that expression of ICAM-1 was positive in 80% to 96% HCC cell surface. The indentical expression rate of surface and serum ICAM-1 in HCC was 87%;the study in ex-vivo domanstrated that serum ICAM-1 was sheded from the HCC tumor itself.We concluded the followings:measurment of serum levels of ICAM-1 may be a useful serum marker for early diagnosing HCC; the changes of serum ICAM-1 level may be a valuable indicator for predicting prognosis and mornitoring clinical course of patients with HCC,which are of great significance in improving the results of diagnosing and treating HCC. |
| Key words: intercellular adhesion molecule hepatocellular carcinoma |
