| 引用本文： |
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苏建家,覃国忠,杨春,严瑞琪,P. D. Lotlikar.IGF-Ⅱ和HBxAg及ras基因在树鼩实验性肝癌组织中的表达[J].广西科学,1997,4(4):309-311. [点击复制]
- Su Jianjia,Qin Guozhong,Yang Chun,Yan Reiqi,P. D. Lotlikar.Expressions of IGF-Ⅱ,HBxAg and ras Gene in the Experimental Hepatocellular Carcinomas in Tree Shrews[J].Guangxi Sciences,1997,4(4):309-311. [点击复制]
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| 摘要: |
| 用免疫组化方法观察胰岛素样生长因子Ⅱ(IGF-Ⅱ)、HBxAg及ras基因的表达蛋白p21在乙肝病毒(HBV)和黄曲霉素B1(AFB1)致树鼩肝癌过程中的表达。发现这三种基因蛋白的表达与肝癌发生呈正相关系。即接受HBV和AFB1双因素的树鼩的肝癌发生率与IGF-Ⅱ、HBxAg及p21的表达阳性率均显著高于只暴露于单一因素HBV或AFB1的动物。同时,在带瘤树鼩中,这三种基因的表达又显著高于无瘤者。提示:HBV与AFB1能协同激发这些基因的异常表达;这些基因的过量表达在肝细胞的癌变过程中起了重要的作用。 |
| 关键词: IGF-Ⅱ HBxAg ras 树鼩 肝癌 |
| DOI： |
| 投稿时间：1997-04-21 |
| 基金项目:自治区卫生厅重点课题。 |
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| Expressions of IGF-Ⅱ,HBxAg and ras Gene in the Experimental Hepatocellular Carcinomas in Tree Shrews |
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Su Jianjia, Qin Guozhong, Yang Chun, Yan Reiqi, P. D. Lotlikar
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| (Guangxi Cancer Institute, 6 Binhulu, Nanning, Guangxi, 530021) |
| Abstract: |
| The expressions of IGF-Ⅱ(insulin-like growth factor Ⅱ),HBxAg(hepatitis B virus) and p21 were detected in the courses of hepatocarcinogenesis induced by HBV (hepatitis B virus) and/or AFB1 (aflatoxin B1) with immunohistochemical method.The parallel relations in the incidence of HCC (hepatocellular carcinoma) and the expressions of these genes have appeared in each group.They were higher in the tree shrews received both HBV and AFB1 than that exposed to HBV or AFB1 alone.On the other hand,the expressions of these genes in tumor-carried tree shrews were significantly higher than that in non-tumor animals. Our results suggested that there was a synergistic effect of HBV and AFB1 in activation of these genes in tree shrews.Over expressions of these genes may take an important role in the courses of hepatocarcinogenesis in tree shrews. |
| Key words: IGF-Ⅱ HBxAg ras tupaia liver cancer |
