| 引用本文： |
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莫宁,王鲁,陈家欢,陈美芳.P物质对大鼠星状神经节细胞的影响[J].广西科学,1997,4(4):306-308. [点击复制]
- Mo Ning,Wang Lu,Chen Jiahuan,Chen Meifang.Effect of Substance P on Rat Stellate Ganglion Neurones[J].Guangxi Sciences,1997,4(4):306-308. [点击复制]
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| 摘要: |
| 应用细胞内生物电记录方法,观察神经肽P物质(SP)对大鼠星状神经节细胞的影响,用灌流或用加压向细胞周围施加SP可使部分细胞发生膜除极反应。用低钙或用含河豚毒素克氏液灌流神经节,并不影响SP引起的除极反应的幅度和时程。SP引起除极反应的同时常伴有膜电阻增大。当膜电位增大时,除极化反应幅度变小,反转电位为-80mV至-100mV,研究表明,SP对部分星状神经节细胞具有直接兴奋作用。并且,SP对细胞膜的除极作用是由于其引起细胞膜钾导降低所至。 |
| 关键词: P物质 交感神经节 星状神经节细胞 细胞内生物电记录 |
| DOI： |
| 投稿时间：1997-09-08 |
| 基金项目: |
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| Effect of Substance P on Rat Stellate Ganglion Neurones |
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Mo Ning, Wang Lu, Chen Jiahuan, Chen Meifang
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| (Dept. of Pharmacology, Guangxi Medical College, 6 Binhulu, Nanning, Guangxi, 530021) |
| Abstract: |
| Intracellular recordings were made from neurones of the isolated rat stellate ganglia. Substance P (SP) applied by superfusion or by pressure ejection elicited a slow depolarization in portion of stellate ganglion cells studied in vitro. The depolarization which persisted in a low Ca2+ solution or the solution containing TTX, was often associated with a increase in neuronal input resistance, and the response was reduced by membrane hyperpolarization and reversed their polarities between -80 mV and 100 mV. Our results suggest that SP is excitatory to stellate ganglion cells directly, and a reduction of membrane K+ conductance constitutes the primary ionic mechanism underlying the depolarizing action of SP. |
| Key words: substance P sympathetic ganglion stellate ganglion neurone intracellular recording |
