| 引用本文： |
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李国秀,柳广南,覃寿明,肖常青,陈一强,许辉,施焕中.干扰素-γ对哮喘患者抗原引起气道嗜酸性粒细胞浸润的影响[J].广西科学,1997,4(2):150-154. [点击复制]
- Li Guoxiu,Liu Guangnan,Qin Shouming,Xiao Changqing,Chen Yiqiang,Xu Hui,Shi Huanzhong.Effect of Interferon-gamma on Antigen-induced Eosinophil Infiltration into the Asthmatic Airway[J].Guangxi Sciences,1997,4(2):150-154. [点击复制]
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| 摘要: |
| 干扰素┐γ对哮喘患者抗原引起气道嗜酸性粒细胞浸润的影响EfectofInterferon┐gammaonAntigen┐inducedEosinophilInfiltrationintotheAsthmaticAirwayLiGuoxiuLiuGua... |
| 关键词: 干扰素-γ 嗜酸性粒细胞 哮喘 |
| DOI： |
| 投稿时间：1997-03-17 |
| 基金项目:广西区科委自然科学基金资助项目。 |
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| Effect of Interferon-gamma on Antigen-induced Eosinophil Infiltration into the Asthmatic Airway |
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Li Guoxiu, Liu Guangnan, Qin Shouming, Xiao Changqing, Chen Yiqiang, Xu Hui, Shi Huanzhong
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| (Department of Internal Medicine, First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021) |
| Abstract: |
| To investigate whether human recombinant interferon-gamma (hrIFN-γ) is capable of inhibiting the antigen-induced eosinophil infiltration into the airways of the patients with allergic bronchial asthma,ten atopic asthmatic subjects were underwent an initial bronchoscopy when the hrIFN-γ plus dust mite were instilled into a subsegment of the lingula or right middle lobe and diluent plus dust mite were instilled into a subsegment of the opposite lung (middle lobe,or lingula).The second bronchoscopy was performed 24 h later,and bronchial mucosa from each treated sites were taken separately.Immunohistochemical technique was used to evaluate the presence of eosinophils and some subsets of T lymphocytes including CD4+,CD8+ and CD25+ cells.Immunostaining revealed decreases in the numbers of total eosinophils (BMK-13+ cells, P<0.01), CD4+ lymphocytes (P<0.01) and CD25+ cells (P<0.05) from IFN-γ treated biopsies compared with control biopsies. However,no difference was observed in the numbers of CD8+ cells.Locally administered hrIFN-γ could prevent the antigen-induced eosinophil recruitment into the asthmatic airways by inhibiting CD4+ T cell infiltration as well as T cell activation.These results suggest that hrIFN-γ may be of value in obtaining clinical improvement in asthmatics. |
| Key words: human recombinant interferon-gamma (hrIFN-γ) eosinophils asthma |
