| 引用本文： |
-
周桂芬,李翠红,仪明光,相正心.3H-二脱水伊地醇双甲磺酸酯在小鼠体内的吸收、分布和排泄[J].广西科学,1997,4(2):143-146. [点击复制]
- Zhou Guifen,Li Cuihong,Yi Mingguang,Xiang Zhengxin.Absorption,Distribution and Excretion of 3H-1,6-Dimesy 1-2,3-4,5 Dianhydro-L-iditol (3H-DMDAI) in Mice[J].Guangxi Sciences,1997,4(2):143-146. [点击复制]
|
|
| 摘要: |
| 采用3H-标记药物的放射性测定法,测定了抗肿瘤药二脱水伊地醇双甲磺酸酯(DMDAI)在小鼠体内的吸收、分布和排泄,并进行了药动学参数统计学处理。结果表明,DMDAI静注时血药浓度分布快,但消除较慢。灌胃给药时吸收迅速。静注和灌胃时组织中分布均以胆汁及肝脏含量较高。静注7d内药物在粪尿中排泄完全,不易蓄积。 |
| 关键词: 二脱水伊地醇双甲磺酸酯 血药浓度 吸收 分布 排泄 小鼠 |
| DOI： |
| 投稿时间：1997-03-03修订日期：1997-04-14 |
| 基金项目: |
|
| Absorption,Distribution and Excretion of 3H-1,6-Dimesy 1-2,3-4,5 Dianhydro-L-iditol (3H-DMDAI) in Mice |
|
Zhou Guifen, Li Cuihong, Yi Mingguang, Xiang Zhengxin
|
| (Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, 20 Guchenglu, Nanning, Guangxi, 530022) |
| Abstract: |
| The absorption,distribution and excretion of antitumour drug 1,6-Dimesy 1-2,3-4,5 Dianhydro-L-iditol(DMDAI) in mice were determined using tritium labeled compound and the two groups of pharmacokinetics parameters of iv and ig were computed and sorted by statistic method.The results showed that the drug concentration in plasma of 3H-DMDAI distributed faster,but eliminated slower after iv.The absorption of 3H-DMDAI was rapid when ig.administration.The drug distribution was found to be high in bile and liver when iv and ig. The total radioactivity was completely excreted in urine and feces within 7 days following iv injection, and it was not easily accumulated. |
| Key words: 1,6-Dimesy 1-2,3-4,5 Dianhydro-L-idito1 drug concentration in plasma absorption distribution excretion mouse |
