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杨斌,龙洁怡,刘永宏.海洋来源活性肽及其抗炎活性研究进展[J].广西科学,2020,27(5):451-461. [点击复制]
- YANG Bin,LONG Jieyi,LIU Yonghong.Research Progress of Marine Bioactive Peptides and Their Anti-inflammation Activity[J].Guangxi Sciences,2020,27(5):451-461. [点击复制]
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| 海洋来源活性肽及其抗炎活性研究进展 |
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杨斌1, 龙洁怡1,2, 刘永宏1,2,3
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| (1.中国科学院南海海洋研究所, 中国科学院热带海洋生物资源与生态重点实验室, 广东省海洋药物重点实验室, 广东广州 510301;2.中国科学院大学, 北京 100049;3.广西中医药大学, 广西南宁 530200) |
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| 摘要: |
| 海洋生物因为其特殊的栖息环境，蕴藏着极其丰富的天然产物，随着对海洋探索的不断发展，越来越多具有抗炎作用的天然产物被发现，其中活性肽类具有靶向性强、活性高、毒性低等特点，药物开发前景良好。本文综述了近几十年来具有抗炎活性的海洋来源活性肽的研究进展，为开发高效安全的抗炎药物提供借鉴。 |
| 关键词: 活性肽 炎症 抗炎活性 天然产物 海洋生物 |
| DOI：10.13656/j.cnki.gxkx.20201214.009 |
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| 基金项目:广西中医药大学海洋药物研究院团队科研专项（2018ZD005），广西八桂学者专项（05019055）和广西中医药大学岐黄工程高层次人才团队培育项目（2018006）资助。 |
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| Research Progress of Marine Bioactive Peptides and Their Anti-inflammation Activity |
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YANG Bin1, LONG Jieyi1,2, LIU Yonghong1,2,3
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| (1.CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, Guangdong, 510301, China;2.University of Chinese Academy of Science, Beijing, 100049, China;3.Guangxi University of Chinese Medicine, Nanning, Guangxi, 530200, China) |
| Abstract: |
| Because of their special habitat,marine organisms contain extremely abundant natural products.With the continuous development of exploration in marine,more and more natural products with anti-inflammatory effects have been discovered.Among them,bioactive peptides have good prospects for drug development due to its advantages of strong targeting,high activity and low toxicity.This article summarizes the research progress of marine-derived bioactive peptides with anti-inflammatory activity in recent decades,and hopes to provide a reference for the development of efficient and safe anti-inflammatory drugs. |
| Key words: bioactive peptides inflammation anti-inflammation activity natural product marine organism |
