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朱绮霞,李一向,成春燕,胡文进,周礼芹.逆转录转座子LINE-1的活性调控及其在癌症中的作用[J].广西科学,2018,25(3):268-273. [点击复制]
- ZHU Qixia,LI Yixiang,CHENG Chunyan,HU Wenjin,ZHOU Liqin.The Regulation of Retrotransposon LINE-1 and Its Function in Tumorigenesis[J].Guangxi Sciences,2018,25(3):268-273. [点击复制]
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| 逆转录转座子LINE-1的活性调控及其在癌症中的作用 |
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朱绮霞1, 李一向2, 成春燕3, 胡文进1, 周礼芹1
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| (1.广西科学院, 国家非粮生物质能源工程技术研究中心, 非粮生物质酶解国家重点实验室, 广西生物炼制重点实验室, 广西南宁 530007;2.南宁市新科健生物技术有限责任公司, 广西南宁 530003;3.广西科学院生物研究所, 广西南宁 530007) |
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| 摘要: |
| 逆转座子长散布核元件-1(LINE-1)是一种跳跃基因,约占人类基因组的17%。LINE-1采用"复制-粘贴"的方式,以RNA为媒介,在基因组中进行转座易位。一般地,细胞中LINE-1的转座活性受到严格调控。而在肿瘤细胞中,LINE-1异常活化,以逆转座依赖或非依赖的方式,影响基因组的稳定性:前者可以改变靶基因表达、引起染色质重排或协助其他转座子(如SINEs等)进行转座;后者为表观遗传的方式,通过产生内源的调节性RNAs、形成LINE-1嵌合性转录、形成新的剪切位点或启动位点来改变临近基因的表达等。本文主要介绍LINE-1的组成及其转座活性调控,并讨论LINE-1转座在肿瘤中的功能,以期为LINE-1的深入研究、肿瘤的形成机制及治疗探索提供一些参考。 |
| 关键词: 逆转座子 LINE-1 癌症 |
| DOI：10.13656/j.cnki.gxkx.20180604.002 |
| 投稿时间：2018-05-04 |
| 基金项目:国家自然科学基金项目(31660018)资助 |
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| The Regulation of Retrotransposon LINE-1 and Its Function in Tumorigenesis |
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ZHU Qixia1, LI Yixiang2, CHENG Chunyan3, HU Wenjin1, ZHOU Liqin1
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| (1.National Engineering Research Center for Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Key Laboratory of Bio-refinery, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China;2.Nanning Newkergen Biotechnology Sciences Co. Ltd., Nanning, Guangxi, 530003, China;3.Biology Institute, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China) |
| Abstract: |
| Long Interspersed Nucleotide Element 1 (LINE-1) is a jumping gene that accounts for about 17% of the human genome.LINE-1 translocates through the genome in a "copy-paste" way, using RNA as a medium.Generally, transposition activity of LINE-1 in cells is strictly regulated.In tumor cells, LINE-1 is abnormally activated, affecting the stability of the genome in a Retrotransposon-dependent or non-dependent manner.The former can change the expression of target genes, cause chromatin rearrangement, or assist other transposons (e.g.SINEs, etc.) in transposition.The latter involves in a variety of activities through epigenetic modalities in cancerous cells, such as the generation of endogenous regulator RNAs, LINE-1 chimeric transcription, or the supply of new shear sites or variable promoters to change the expression of adjacent genes.This article mainly introduces the composition of LINE-1 and its regulation of transposition activity, and discusses the function of LINE-1 transposition in tumors, in order to provide some references for the in-depth study of LINE-1, the mechanism of tumor formation and therapeutic exploration. |
| Key words: retrotransposon LINE-1 tumorigenesis |
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