| 引用本文： |
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梁鹏宇,潘霞,任宇豪,刘伟治.溶栓酶的研究进展[J].广西科学,2017,24(1):77-82. [点击复制]
- LIANG Pengyu,PAN Xia,REN Yuhao,LIU Weizhi.Research Progress of Thrombolytic Enzymes[J].Guangxi Sciences,2017,24(1):77-82. [点击复制]
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| 摘要: |
| 随着人口老龄化的加剧及人们生活方式的改变,血栓类疾病已日益严重,成为当今人类健康的重大威胁,基于溶栓药物的治疗是血栓类疾病治疗的重要方法。本文首先概述了血栓的类型、形成机制及溶栓酶溶栓机制,然后总结了溶栓药物的发展、新型天然溶栓酶及制剂、溶栓酶制备方法的研究进展,最后指出获得溶栓效率高、成本低的新型天然溶栓药物是未来血栓类疾病治疗的重要研究方向 |
| 关键词: 血栓类疾病 溶栓酶 生物制药 酶工程 |
| DOI：10.13656/j.cnki.gxkx.20170116.002 |
| 投稿时间：2016-12-26 |
| 基金项目:国家自然科学基金项目(81302684),山东省自然科学基金项目(ZR2013CM044)和高等学校博士学科点专项科研基金项目(20130132120031)资助 |
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| Research Progress of Thrombolytic Enzymes |
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LIANG Pengyu, PAN Xia, REN Yuhao, LIU Weizhi
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| (College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong, 266003, China) |
| Abstract: |
| With the aggravating trend of aging population and changes in people's lifestyles, increasingly serious thrombotic diseases have become a major threat to human health today.Therapy based on thrombolytic drugs is an important method of treatment to thrombotic diseases.First, this paper reviews the types of thrombosis, the mechanism of formation and thrombolytic mechanism, then it summarizes the development of thrombolytic drugs, new natural thrombolytic enzymes and preparations, methods of thrombolytic enzyme preparation of research progress, and finally it points out that new natural thrombolytic drugs with high thrombolytic efficiency, low cost is the important research direction of thrombotic diseases treatment in the future. |
| Key words: thrombotic diseases thrombolytic enzymes biopharmaceutical enzyme engineering |
