| 摘要: |
| 酮酶对于多种生物代谢途径至关重要,且对碳碳键的生物合成起关键作用。目前,对脱羧的克莱森缩合反应研究较为深入,而催化非脱羧克莱森缩合反应的酮酶的研究工作相对较少。最近,在这方面的研究取得了一些新的进展。本文论述了与之相关的新型酮酶的酶学特性、结构基础、催化机制以及应用前景。 |
| 关键词: 非脱羧 克莱森缩合反应 酮酶 |
| DOI：10.13656/j.cnki.gxkx.20170119.001 |
| 投稿时间：2016-12-19 |
| 基金项目:国家自然基金项目(31660251)资助 |
|
| Novel Ketosynthases of Catalyzing the Non-decarboxylative Claisen Condensation |
|
PAN Lixia, YANG Dengfeng
|
| (State Key Laboratory of Non-food Biomass and Enzyme Technology, National Engineering Research Center of Non-food Biorefinery, Guangxi Biomass Industrialization Engineering Institute, Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China) |
| Abstract: |
| Ketosynthases are essential for several metabolic pathways and play a vital function in biosynthesis of carbon-carbon bond. Until now, decarboxylative Claisen reaction has been intensitively studied, while the research of ketosynthases which catalyzed the non-decarboxylative Claisen condensations is relatively scarce. Recently, some new progresses have been made in this field. In this paper, novel ketosynthases have been discussed including their enzymatic characteristics, structure basis, catalytic mechanism and application prospect. |
| Key words: non-decarboxylative Claisen condensation ketosynthase |
