| 引用本文： |
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李燕婧,钟正贤,陈学芬.黄杞总黄酮的抗血栓作用及其机理研究[J].广西科学,2015,22(2):143-147,152. [点击复制]
- LI Yan-jing,ZHONG Zheng-xian,CHEN Xue-fen.Experimental Study of Total Flavonoids of Engelhardtia roxburghiana on Antithrombotic Effects and Its Mechanisms[J].Guangxi Sciences,2015,22(2):143-147,152. [点击复制]
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| 摘要: |
| [目的]探讨黄杞总黄酮(TFER)的抗血栓形成作用及其机理,为进一步评估和研发黄杞的抗血栓形成作用提供实验依据。[方法]建立3种实验性血栓形成模型:大鼠腹主动脉血栓模型、大鼠体内静脉血栓模型、大鼠"衰老加血瘀证"血栓模型,观察TFER的抗血栓作用,研究其机理。[结果]TFER能延长腹主动脉血栓形成大鼠血浆凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT),降低纤维蛋白原(Fib)含量,同时能缩短血栓长度,降低血栓形成率;能减轻体内静脉血栓形成大鼠的血栓湿重;能降低大鼠血清血栓素(TXB2)、内皮素1(ET-1)、纤溶酶原激活物抑制物(PAI)、丙二醛(MDA)含量以及脑组织MDA和脂褐质(Lf)含量,同时提高大鼠血清前列环素(PGI2)、纤溶酶原激活物(t-PA)、超氧化物歧化酶(SOD)含量。[结论] TFER具有抗血栓作用,其作用可能是通过调节凝血功能,调节血小板聚集反应,改善纤溶平衡异常,抑制脂质过氧化反应从而达到抗血栓作用。 |
| 关键词: 黄杞总黄酮 抗血栓作用 机制研究 大鼠 |
| DOI：10.13656/j.cnki.gxkx.20150511.001 |
| 投稿时间：2014-10-15修订日期：2015-03-13 |
| 基金项目:广西卫生厅中医药专项(GZPT13-28)资助。 |
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| Experimental Study of Total Flavonoids of Engelhardtia roxburghiana on Antithrombotic Effects and Its Mechanisms |
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LI Yan-jing1,2, ZHONG Zheng-xian1,2, CHEN Xue-fen1
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| (1.Guangxi Institute of Traditional Medical and Pharmaceutical Science, Nanning, Guangxi, 530022, China;2.Guangxi Key Laboratory of Tradtitonal Chinese Medicine Quality Stardands, Nanning, Guangxi, 530022, China) |
| Abstract: |
| [Objective] The antithrombotic effects of TFER and its mechanisms were investigated in order to provide an experimental evidence for the further evaluation and research of the antithrombosis of Engelhardia roxburghiana Wall.[Methods] Three antithrombotic models were set up in rats, including the model of abdominal aorta thrombosis, the model of venous thrombosis and the model of aging and stasis, and the antithrombotic effects and mechanisms of TFER were observed.[Results] TFER can increase thrombin time(TT), prothrombin time(PT), activated partiac thrombin time(APTT), decrease the content of fibrinogen(Fib), shorten the length of thrombus, and decrease the rate of thrombosis and the wet weight of thrombus;TFER can decrease the content of TXB2, ET-1, PAI and MDA in serum, and decrease the content of MDA and Lf in cerebral tissue, meanwhile it can increase the content of PGI2, t-PA and SOD.[Conclusion] TFER has obvious antithrombotic effects, of which TFER functions through regulating coagulation function, improving fibrinolytic balance, and restraining lipid peroxidation. |
| Key words: total flavonoids of Engelhardtia roxburghiana antithrombotic effect mechanisms rat |
