| 引用本文： |
-
孙雪萍,徐艳,宋成芝,童万平.毛蚶正丁醇相抗卤虫化学成分分析[J].广西科学,2013,20(4):272-275. [点击复制]
- SUN Xue-ping,XU Yan,SONG Cheng-zhi,TONG Wan-ping.Bioactivity Evaluation and Constituent Analysis of the n-butanol Fractions from Scapharca Subcrenata Lischke[J].Guangxi Sciences,2013,20(4):272-275. [点击复制]
|
|
| 摘要: |
| 应用抗卤虫(Artemia salina)生物活性筛选模型,分析南海毛蚶(Scapharca subcrenata)乙醇浸膏和正丁醇相的生物活性成分。从毛蚶(S.subcrenata)正丁醇萃取相中共分得4个化合物,包括3个甾体类化合物5-烯-胆甾醇(1),胆甾醇(2),3-酮-20-烯孕甾烷(3)和1个吲哚类化合物3-carboxy-indole(4),化合物(1)~(3)在50μg/mL时对卤虫的致死率分别为65.0%,60.0%和58.3%。 |
| 关键词: 毛蚶 甾体 生物活性 |
| DOI： |
| 投稿时间：2013-07-30修订日期：2013-08-26 |
| 基金项目:广西科学研究与技术开发计划项目(桂科攻11107011-8);广西科学院基本科研业务费项目(13YJ22HYS15);广西科学研究与技术开发计划项目(桂科攻11107011-6)资助。 |
|
| Bioactivity Evaluation and Constituent Analysis of the n-butanol Fractions from Scapharca Subcrenata Lischke |
|
SUN Xue-ping1, XU Yan1, SONG Cheng-zhi2, TONG Wan-ping1
|
| (1.Guangxi Institute of Oceanology, Guangxi Key Laboratory of Marine Biotechnology, Beihai, Guangxi, 536000, China;2.Zhaotong Teacher's College, Department of Chemistry, Zhaotong, Yunnan, 657000, China) |
| Abstract: |
| The bioactivities of ethanolic extract and n-butanol fractions of Scapharca subcrenata from the South China Sea were evaluated by the model of lethality to brine shrimp Artemia salina.The ethanolic extract and n-butanol fractions showed lethality.The compounds in the n-butanol were separated, and four compounds were identified as cholest-5-en-3-ol (1), Cholesterol (2), 5a-pregn-20-en-3-one (3) and 3-carboxy-indole (4).The compounds 1~3 belong to sterols and their lethal rate was 65.0%, 60.0% and 58.3% in 50 μg/mL, respectively, suggesting that these steroids should be the bioactive substances of S.Subcrenata lischke. |
| Key words: Scapharca subcrenata lischke steroids bioactivity |
