| 摘要: |
| 利用十六烷基三甲基溴化铵催化氯乙酸和2-氯苯酚合成2-氯苯氧乙酸,十六烷基三甲基溴化铵具有较高的催化活性,可以加快合成2-氯苯氧乙酸。反应过程考察了2-氯苯酚与氯乙酸摩尔比、催化剂用量、反应时间、反应温度对产率的影响以及催化剂的重复使用性能。反应的最佳条件为:在85℃下,2-氯苯酚和氯乙酸的摩尔比为1:4,催化剂质量为0.3g,反应时间为3.5h。此反应所得到的2-氯苯氧乙酸的产率为50.50%。该催化剂的用量很少,而且易于回收,可以重复使用。 |
| 关键词: 2-氯苯氧乙酸 氯乙酸 2-氯苯酚 十六烷基三甲基溴化铵 合成 |
| DOI： |
| 投稿时间：2010-06-01 |
| 基金项目:广西自然科学基金课题(桂科自0899022);广西教育厅课题(200710LX149) |
|
| Catalytic Synthesis of 2-Chlorophenoxyacetic Acid |
|
NONG Bang-xie1, HUANG Suo-yi2
|
| (1.Department of Clinical Medicine, Youjiang Medical College for Nationalities, Baise, Guangxi, 533000, China;2.Department of Pharmacy, Youjiang Medical College for Nationalities, Baise, Guangxi, 533000, China) |
| Abstract: |
| The use of cetyltrimethylammonium bromide catalyzed chloroacetate and 2-chlorophenol synthesis of 2-chlorophenoxyacetic acid.Cetyltrimethylammonium bromide has a higher catalytic activity and can accelerate the synthesis of 2-chlorophenoxyacetic acid.The reaction is studied on 2-chlorophenol and chloroacetic acid molar ratio, catalyst amount, reaction time and temperature on yield, and the performance of repeated use of catalyst.The best reaction conditions are as follows:at 85℃, 2-chlorophenol and chloroacetate molar ratio of 1:4, catalyst weight of 0.3g, reaction time of 3.5h, which get 2-chlorophenoxyacetic acidproduction rate of 50.50%.This catalyst is characterized by small amount, easy recovery, and can be reused. |
| Key words: 2-chlorophenoxyacetic acid chloroacetate 2-chlorophenol cetyltrimethylammonium bromide synthesis |
