| 引用本文： |
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陈丽,葛为公,裴世成,李慧萍,吴钢.芦丁壳聚糖缓释片体外释放度研究[J].广西科学,2009,16(4):438-440. [点击复制]
- CHEN Li,GE Wei-gong,PEI Shi-cheng,LI Hui-ping,WU Gang.Study on the in Vitro Release Rate of Rutin Sustained-release Tablets Containing Chitosan[J].Guangxi Sciences,2009,16(4):438-440. [点击复制]
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| 摘要: |
| 以壳聚糖为骨架材料制备芦丁壳聚糖缓释片,并用高效液相色谱法考察其体外释放度。结果芦丁壳聚糖缓释片在30min、60min、120min、180min、240min、360min、480min、720min的体外释放度为(11.37±0.96)%、(18.66±1.09)%、(28.26±0.94)%、(35.72±1.22)%、(41.37±1.20)%、(53.22±1.20)%、(60.66±0.85)%、(75.39±1.32)%。壳聚糖对芦丁具有缓释作用,药物的体外释放符合Higuchi方程。 |
| 关键词: 释放度 缓释片 壳聚糖 芦丁 高效液相色谱法 |
| DOI： |
| 投稿时间：2009-04-17修订日期：2009-06-15 |
| 基金项目:广西壮族自治区卫生厅科研基金项目(No:Z2007321)资助 |
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| Study on the in Vitro Release Rate of Rutin Sustained-release Tablets Containing Chitosan |
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CHEN Li1, GE Wei-gong2, PEI Shi-cheng1, LI Hui-ping1, WU Gang1
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| (1.Liuzhou Medical College, Liuzhou, Guangxi, 545006, China;2.Guilin Medical College, Guilin, Guangxi, 541001, China) |
| Abstract: |
| Chitosan was chosen as framework material for the preparation of rutin sustained-release tablet.Furthermore, the in vitro release rate was evaluated.Result:The in vitro release rates of the self-preparation (rutin sustained-release tablets in chitosan framework material) were (11.37±0.96)%、(18.66±1.09)%、(28.26±0.94)%、(35.72±1.22)%、(41.37±1.20)%、(53.22±1.20)%、(60.66±0.85)%、(75.39±1.32)%, at 30min, 60min, 120min, 180min, 240min, 360min, 480min, 720min respectively.Chitosan can slower the release rate of rutin preparation when chitosan was chosen as the framework material.The release profile followed Higuchi kinetics formula. |
| Key words: dissolution sustained-release tablets chitosan Rutin High Performance Liquid Chromatography |
