| 摘要: |
| 从花生四烯酸(AA)代谢途径、细胞因子及其受体、细胞内第二信使、活性氧、一氧化氮、血小板活化因子及其受体、核因子、细胞间粘附分子等多个方面对当前中药抗炎分子机制的研究进展进行综述,认为该领域的研究已发展到从炎症的不同途径和环节在分子水平对中药抗炎的作用机制进行了研究,但对绝大多数中药抗炎作用的具体作用过程还了解得不够详细、全面,在基因水平的研究也还比较少。建议今后应该从与炎症有关的信号转导途径、AA代谢途径中的环氧化酶(COX)异构酶及其下游的前列腺素(PGs)合成酶系和相应受体、磷酸二酯酶及其同功酶等更多的抗炎途径和环节对中药抗炎作用的分子机制进行更深入研究。 |
| 关键词: 中药 抗炎作用 分子机制 研究进展 |
| DOI： |
| 投稿时间：2004-12-07修订日期：2005-01-24 |
| 基金项目: |
|
| Progress of the Study on Molecular Mechanism of Traditional Chinese Medicine on Anti-inflammatory Effect |
|
Yang Jie, Liu Huagang
|
| (Pharmacology Department, Guangxi Medical Univ., Nanning, Guangxi, 530021, China) |
| Abstract: |
| To review the progress of the study on molecular mechanism of traditional Chinese medicine on anti-inflammatory effect from many aspects,such as arachidonic acid metabolism pathway,cytokine and its receptor,cell second messenger,active oxygen,nitrogen monoxidum,platelet activating factor and its receptor,nuclear factor,intercellular adhesion molecule etc.In conclusion,the study have already developed to the molecular level and related to defferent anti-inflammatory pathways and links,but the specific anti-inflammatory process of most traditional Chinese medicine and seldom studied on gene level is still unknown.It suggests that we should study in-depth in more anti-inflammatory pathways and links,such as the inflammatory signal transduction,COX isoenzymes or their downstream PGs synthase system and their corresponding receptor in arachidonic acid metabolism pathway,phosphodiesterase and its isoenzymes and so on. |
| Key words: traditional Chinese medicine anti-inflammatory effect molecular mechanism progress of study |
