| 引用本文： |
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邓卓霖,韦义萍,马韵.解毒酶GSTM1和GSTT1缺失与广西肝细胞癌相关性研究[J].广西科学,2005,12(1):55-57. [点击复制]
- Deng Zhuolin,Wei Yiping,Ma Yun.Genetic Deletion of GSTM1 and GSTT1 Detoxicated Enzymes in Relation to Hepatocellular Carcinoma in Guangxi[J].Guangxi Sciences,2005,12(1):55-57. [点击复制]
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| 摘要: |
| 为了研究谷胱甘肽硫转移酶GSTM1和GSTT1基因多态性与肝细胞癌风险的相关性,在广西黄曲霉毒素(AFB1)高污染区,用PCR技术检测肝细胞癌患者和非肝细胞癌成人血样中GSTM1和GSTT1的存在或缺失。肝细胞癌组(HCC)181例,经病理确诊为肝细胞癌,对照组360例,由非肝细胞癌成人组成。结果显示,GSTM1和GSTT1零基因型的频率在对照组分别为47.8%和42.7%,在肝细胞癌组分别为64.6%和59.7%,两组间的差异有非常显著性意义(P<0.01)。GSTM1和GSTT1联合零基因型在肝细胞癌组与对照组分别为38.2%和18.5%,两组间差异有显著性意义(P<0.05)。说明GSTM1和GSTT1零基因型在当地与AFB1诱发肝细胞癌的风险相互关联。 |
| 关键词: 肝细胞癌 黄曲霉毒素B1 谷胱甘肽硫转移酶 |
| DOI： |
| 投稿时间：2004-03-19 |
| 基金项目:国家自然科学基金(39860032)和广西教育厅重点资助课题基金(98-2-8)资助项目。 |
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| Genetic Deletion of GSTM1 and GSTT1 Detoxicated Enzymes in Relation to Hepatocellular Carcinoma in Guangxi |
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Deng Zhuolin1, Wei Yiping2, Ma Yun1
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| (1.Dept. of Pathology, Guangxi Medical Univ., Nanning, Guangxi, 530021, China;2.Nurse Training Coll., Guangxi Medical Univ., Nanning, Guangxi, 530021, China) |
| Abstract: |
| The present study was undertaken to evaluate the association between GSTM1 and GSTT1 gene polymorphisms and risk of hepatocellular carcinoma.Cases and controls study the genetic polymorphisms of the genes at an aflatoxin high contaminated region in Guangxi.Polymerase chain reaction (PCR) technique was used to detect the presence or absence of the GSTM1 and GSTT1 genes at the blood samples.The case group was composed of 181 patients of HCC identified by the pathologist and the control group was composed of 360 adults without any tumor.The frequencies of GSTM1 and GSTT1 null genotype in the control were 47.8% and 42.7% respectively,while in the HCC group were 64.6% and 59.7% respectively.The differences between HCC group and the control group were very significant,P <0.01.GSTM1 and GSTT1 combined null genotype in HCC group and control group were 38.2% and 18.5%,the difference was significant (P <0.05).The GSTM1 and GSTT1 null genotypes were associated with an increased risk of HCC in this AFB1 high contaminated region. |
| Key words: hepatocellular carcinoma aflatoxin B1 Glutathione S-transferase |
