| 引用本文： |
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钟正贤,周桂芬,莫恃,刘布鸣.维生素K3对安定血药浓度及药理作用的影响[J].广西科学,1997,4(3):217-219,232. [点击复制]
- Zhong Zhengxian,Zhou Guifen,Mo Shi,Liu Buming.Effect of Vitamin K3 on Blood-drug Concentration and Pharmacologic Action of Diazepam[J].Guangxi Sciences,1997,4(3):217-219,232. [点击复制]
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| 摘要: |
| 用动物实验研究了维生素K3对安定血药浓度及药理作用的影响。结果表明,维生素K3能明显缩短安定血药浓度分布半衰期和消除半衰期,提高安定体内清除率。增加家兔呼吸频率,但不影响麻醉后家兔的心电图、血压和心率。能缩短安定所致小鼠睡眠时间,具有催醒作用。 |
| 关键词: 维生素K3 安定 血药浓度 药理作用 |
| DOI： |
| 投稿时间：1997-05-16修订日期：1997-06-25 |
| 基金项目:广西壮族自治区人民医院麻醉科。 |
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| Effect of Vitamin K3 on Blood-drug Concentration and Pharmacologic Action of Diazepam |
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Zhong Zhengxian, Zhou Guifen, Mo Shi, Liu Buming
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| (Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, 20 Guchenglu, Nanning, Guangxi, 530022) |
| Abstract: |
| The effect of vitamin K3 on blood-drug concentration and pharmacologic action of diazepam was studied by animal experiment.The results showed that vitamin K3 could markedly shorten distributed half-life and eliminate half-life,and increase elimination rate of diazepam in body,enhance breathe frequency, but no effect on electrocardiogram,blood pressure and heart rate of rabbits after anaesthesia.Vitamin K3 can shorten sleep-time induced by diazepam in mices,possessing analeptic action. |
| Key words: vitamin K3 diazepam blood-drug concentration pharmacologic action |
