| 引用本文： |
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杨登峰,黄艳冰,潘丽霞,李红亮,阳丽艳.红树林来源真菌生物碱类天然产物研究进展[J].广西科学院学报,2023,39(4):349-362. [点击复制]
- YANG Dengfeng,HUANG Yanbing,PAN Lixia,LI Hongliang,YANG Liyan.Research Progress of Alkaloids Natural Products from Marine Mangrove Fungi[J].Journal of Guangxi Academy of Sciences,2023,39(4):349-362. [点击复制]
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| 摘要: |
| 海洋天然产物在药物开发方面一直发挥着非常重要的作用。红树林作为特殊的生态系统，蕴含着丰富的微生物资源，是新型药物先导化合物发现的优质天然资源宝库。红树林来源真菌生物碱通常结构新颖，生物活性显著，是理想的新药先导化合物，具有良好的研究和应用价值。近年来，红树林来源真菌生物碱类天然产物研究日益发展，本文根据生物碱的不同来源，按照鸟氨酸系、色氨酸系、苯丙氨酸系、邻氨基苯甲酸系、二酮哌嗪类以及其他类生物碱进行分类，总结了2015-2021年红树林来源真菌中挖掘到的116个新颖的生物碱类次级代谢产物及其生物活性，拟为红树林来源真菌生物碱类次级代谢产物的研究提供参考。 |
| 关键词: 红树林 真菌 次级代谢产物 生物碱 生物活性 |
| DOI：10.13657/j.cnki.gxkxyxb.20231226.002 |
| 投稿时间：2023-09-11修订日期：2023-11-20 |
| 基金项目:国家自然科学基金项目(31960203)，广西科技基地与人才专项(桂科AD23023007)和广西海洋天然产物与组合生物合成化学重点实验室科研业务费项目(GXNNPC2020007)资助。 |
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| Research Progress of Alkaloids Natural Products from Marine Mangrove Fungi |
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YANG Dengfeng1, HUANG Yanbing1, PAN Lixia2, LI Hongliang1, YANG Liyan2
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| (1.Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Academy of Marine Science (Guangxi Mangrove Research Center), Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China;2.National Key Laboratory of Non-food Biomass Energy Technology, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China) |
| Abstract: |
| Marine natural products have always played a very important role in drug development.As a special ecosystem,mangrove contains abundant microbial resources and is a treasure house of high-quality natural resources for the discovery of new drug lead compounds.Alkaloids isolated from mangrove fungi are usually novel in structure and have significant bioactivities,which are ideal sources of lead compounds for new drug discovery and have good research and application value.In recent years,the research on alkaloids natural products of mangrove-derived fungi has been developing rapidly.According to the different sources of alkaloids,the alkaloids were classified according to ornithine,lysine,tryptophan,phenylalanine,diketopiperazine and other alkaloids.And 116 novel alkaloids secondary metabolites and their biological activities excavated from mangrove-derived fungi were summarized from 2015 to 2021 in this article.It is intended to provide reference for the study of alkaloids secondary metabolites of mangrove-derived fungi. |
| Key words: mangrove fungi secondary metabolite alkaloids biological activities |
