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朱源,李检秀,李坚斌,黄日波.药用植物中四环三萜皂苷合成生物学研究进展[J].广西科学院学报,2020,36(3):309-316. [点击复制]
- ZHU Yuan,LI Jianxiu,LI Jianbin,HUANG Ribo.Research Progress in Synthetic Biology of Tetracyclic Triterpenoids Saponins in Medicinal Plants[J].Journal of Guangxi Academy of Sciences,2020,36(3):309-316. [点击复制]
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| 药用植物中四环三萜皂苷合成生物学研究进展 |
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朱源1,2, 李检秀1, 李坚斌2, 黄日波1
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| (1.广西科学院, 非粮生物质酶解国家重点实验室, 国家非粮生物质能源工程技术研究中心, 广西生物质工程技术研究中心, 广西生物炼制重点实验室, 广西南宁 530007;2.广西大学轻工与食品工程学院, 广西南宁 530004) |
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| 摘要: |
| 萜类化合物是药用植物中结构和生物活性多样化的一类大分子化合物，是自然界中广泛存在的次级代谢产物，主要应用于食品、保健品、医药等领域。生物信息学和分子生物学研究的不断深入，极大促进了药用植物四环三萜皂苷的生物合成途径解析与关键功能基因的挖掘鉴定。本文对常见药用植物四环三萜皂苷的生物合成学研究现状展开论述，重点介绍以药用植物四环三萜皂苷为代表的几类化合物的分子合成机制和生物合成研究进展，为人工构建、优化微生物“细胞工厂”，高效合成稀有、高附加值的四环三萜类化合物，推动药用植物资源可持续利用等提供参考。 |
| 关键词: 药用植物 合成生物学 次级代谢产物 萜类化合物 四环三萜皂苷 |
| DOI：10.13657/j.cnki.gxkxyxb.20201027.018 |
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| 基金项目:中国科学院科技服务网络计划（STS计划），广西甘蔗产业科技专项（No.KFJ-STS-QYZD-200），中央引导地方科技发展专项（桂科ZY1949015），广西自然科学基金青年基金项目（2018GXNSFBA281017）和广西重大科技创新基地建设项目（No.2018-15-Z03）资助。 |
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| Research Progress in Synthetic Biology of Tetracyclic Triterpenoids Saponins in Medicinal Plants |
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ZHU Yuan1,2, LI Jianxiu1, LI Jianbin2, HUANG Ribo1
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| (1.State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China;2.College of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi, 530004, China) |
| Abstract: |
| Terpenoids are a class of macromolecular compounds with diversified structures and biological activities in medicinal plants. They are secondary metabolites widely existing in nature and are mainly used in food, health products, medicine and other fields. The continuous in-depth researches on bioinformatics and molecular biology have greatly promoted the analysis of biosynthetic pathways and the identification of key functional genes of tetracyclic triterpenoid saponins in medicinal plants. This article discusses the biosynthetic research status of common medicinal plant tetracyclic triterpenoids saponins, and focuses on the molecular synthesis mechanism and biosynthetic research progress of several types of compounds represented by medicinal plant tetracyclic triterpenoids saponins. These examples provide a reference for artificially constructing and optimizing microbial cell factories, efficiently synthesizing rare, high value-added tetracyclic triterpenoids, and promoting the sustainable utilization of medicinal plant resources. |
| Key words: medicinal plants synthetic biology secondary metabolites terpenoids tetracyclic triterpenoids saponins |
