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鱼类免疫因子Prx 1和Prx 2的研究进展
郑琦, 邹子鸿, 蔡佳, 简纪常
0
(广东海洋大学)
摘要:
Peroxiredoxin 1(Prx 1)和Peroxiredoxin 2(Prx 2)是脊椎动物中一种保守的免疫因子,在鱼类的非特异性免疫中扮演重要角色,也叫作自然杀伤增强因子(Natural Killer Enhancing Factor, NKEF A/B)。两类蛋白的N端和C端各含有一个活性半胱氨酸位点。Prx 1和Prx 2能清除机体清除活性氧ROS和H2O2,同时还参与了鱼体的抗病免疫。本文对鱼类Prx 1和Prx 2的结构、抗氧化机制、生物学功能进行综述性介绍。
关键词:  鱼类,Peroxiredoxin,免疫
DOI:
投稿时间:2019-07-05修订日期:2019-08-06
基金项目:国家自然科学基金(31302226, 31572651)和广东海洋大学优秀硕士学位论文培育项目(201833)资助
Advance in Peroxiredoxin 1 and Peroxiredoxin 2 of Teleost
ZHENG Qi, ZOU Zihong, CAI Jia, JIAN Jichang
(Guangdong Ocean University)
Abstract:
Peroxiredoxin 1 and Peroxiredoxin 2 (Prx 1 and Prx 2) are two conserved immune factors in vertebrates, play important roles in teleost innate immunity, which also known as Natural Killer Enhancing Factor (NKEF A/B). N/ Both C-terminal and N-terminal of Prx 1 and Prx 2 have an active Cys site, respectively. Prx 1 and Prx 2 proteins can erase reactive oxygen species ROS and H2O2 and participate in Anti-pathogeny immune responses. This paper reviews the study of fish Prx 1 and Prx 2 in recent years.
Key words:  Teleost, Peroxiredoxin, Immunity

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