| 摘要: |
| 根据氨基酸对可预测性分析人血红蛋白β链的244个变异,以确定哪些氨基酸对对变异更敏感。结果发现4种变异模式:(1)85.66%的变异发生在不可预测的氨基酸对,(2)绝大多数被替换掉的氨基酸对中包含一个或两个氨基酸对它们的实际频率大于预测频率,(3)79.51%的变异中被替换出的氨基酸对包含一个或两个在正常人β血红蛋白中不存在的氨基酸对,(4)大多数变异缩小了氨基酸对实际频率与预测频率之差。说明变异通常导致人血红蛋白β链的构成更随机、更稳定。 |
| 关键词: 氨基酸对可预测性 血红蛋白β链 变异 模式 |
| DOI： |
| 投稿时间：2010-10-18 |
| 基金项目:supported by Guangxi Science Foundation(10-046-06,2010GXNSFA013046 and 2010GXNSFF013003 and Guangxi Academy of Sciences(08 YJ6SW06) |
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| Mutation Pattern of Amino-Acid Pairs in Human Hemoglobin β-Chain |
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| Abstract: |
| 244 mutations in human hemoglobin β-chain were analyzed in terms of amino-acid pair predictability in order to determine which amino-acid pairs were more sensitive to mutations.The results revealed four mutation patterns,characterized by(1) 85.66% of mutations occurred at unpredictable amino-acid pairs,(2) the vast majority of substituted amino-acid pairs had one or both pairs whose actual frequency larger than predicted one,(3)79.51% of mutations generated one or both substituting amino-acid pairs that were absent in the normal human-hemoglobin and(4) most mutations narrowed the difference between actual and predicted frequencies in amino-acid pairs.Thus,the mutations generally led the human hemoglobin β-chain variants to be constructed more randomly and stably. |
| Key words: amino-acid pair predictability hemoglobin β-chain mutation pattern |
