| 引用本文： |
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姚东方,李杰恩.维生素E琥珀酸酯诱导肿瘤细胞凋亡作用机制的研究进展[J].广西科学院学报,2010,26(2):146-149. [点击复制]
- YAO Dong-fang,LI Jie-en.Research Progress about the Mechanisms of Vitamin E Succinate-induced Apoptosis of Cancer Cells[J].Journal of Guangxi Academy of Sciences,2010,26(2):146-149. [点击复制]
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| 摘要: |
| 维生素E琥珀酸酯是维生素E的衍生物。维生素E琥珀酸酯对肿瘤细胞有显著的凋亡杀伤作用,而对正常细胞没有明显的毒性反应。维生素E琥珀酸酯诱导肿瘤细胞凋亡的机制主要有线粒体途径、脂肪酸合成酶信号系统、MAPK途径、蛋白激酶C等途径。这些机制的研究发现可以为开发出新型与VES抗肿瘤作用同一靶分子的抗肿瘤药物开辟新途径。 |
| 关键词: 维生素E琥珀酸酯 肿瘤细胞 凋亡 |
| DOI： |
| 投稿时间：2010-03-21 |
| 基金项目:广西自然科学基金项目(编号：桂科基0779029)资助。 |
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| Research Progress about the Mechanisms of Vitamin E Succinate-induced Apoptosis of Cancer Cells |
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YAO Dong-fang, LI Jie-en
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| (Department of Otorhinolaryngology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China) |
| Abstract: |
| Vitamin E Succinate (VES) is the derivate of vitamin E.VES can effectively inhibit many kinds of tumors without toxic effects on normal cells and tissues.There are many aspects about the mechanism of VES-induced apoptosis of cancer cells:Mitochondria pathway,Fas pathway TGF-pathway,MAPK pathway and PKC pathway.These discoveries may contribute to develop a new kind of antineoplastic drug that shares the same target molecule with VES. |
| Key words: Vitamin E Succinate cancer cell apoptosis |
