| 引用本文： |
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严少敏,左文朴,朱绮霞,黄艳燕,潘丽霞,吴光.甲型流感病毒基质蛋白2家族的跨种属感染和跨亚型变异的统计学证据[J].广西科学院学报,2010,26(1):45-51. [点击复制]
- YAN Shao-min,ZUO Wen-pu,ZHU Qi-xia,HUANG Yan-yan,PAN Li-xia,WU Guang.Statistical Evidence for Cross-Species Infection and Cross-Subtype Mutation in Matrix Protein 2 Family of Influenza A Virus[J].Journal of Guangxi Academy of Sciences,2010,26(1):45-51. [点击复制]
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| 摘要: |
| 从统计学视角分析甲型流感病毒基质蛋白2(M2)的种属差异和亚型差异。首先,用氨基酸对的可预测性将1129个M2蛋白质转换成1129标量数据,然后用Ⅰ型ANOVA分析这些数据,寻找是否存在种属和亚型的区别,最后用Ⅱ型ANOVA确定组间和组内的差异,进一步追踪跨种属感染和跨亚型突变的原因。得到3条统计学证据,说明甲型流感病毒可能发生跨种属感染和跨亚型突变,其原因是由于各种属和亚型之间的屏障不够强壮,导致突变易于跨越到其它种属或亚型。 |
| 关键词: 氨基酸对 甲型流感病毒 基质蛋白2 种属 亚型 变异 方差分析 |
| DOI： |
| 投稿时间：2009-11-01 |
| 基金项目:This study was partly supported by National Science and Technology Platform Construction (2008FU115XB), Guangxi Science Foundation (0907016 and 0991080) and Guangxi Academy of Sciences (09YJ17SW07). |
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| Statistical Evidence for Cross-Species Infection and Cross-Subtype Mutation in Matrix Protein 2 Family of Influenza A Virus |
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YAN Shao-min1, ZUO Wen-pu1, ZHU Qi-xia1, HUANG Yan-yan1, PAN Li-xia1, WU Guang2
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| (1.National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China;2.Computational Mutation Project, DreamSciTech Consulting, Shenzhen, Guangdong, 518054, China) |
| Abstract: |
| The species and subtype differences were analyzed in the matrix 2 (M2) proteins of influenza A viruses from a statistical viewpoint. First,the amino-acid pair predictability was used to convert 1129 M2 proteins into 1129 scalar data;Second,the model Ⅰ ANOVA was used to analyze these data in terms of species and subtype in order to find if they are distinguishable; Third,the model Ⅱ ANOVA was used to determine the inter-and intra-species/subtype variations to further trace the reason for cross-species infection and cross-subtype mutation. The results provide three pieces of statistical evidence to demonstrate why the cross-species infection and cross-subtype mutation are possible because the barriers between species and between subtypes are not strong enough, which leads a mutation to easily jump to another species or subtype. |
| Key words: amino-acid pair influenza A virus matrix protein 2 species subtype variation ANOVA |
