| 引用本文： |
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徐艳娟,杨亦萍,曹阳,卿海云.Kiss-1基因抑制肿瘤转移的研究进展[J].广西科学院学报,2008,24(1):45-48. [点击复制]
- XU Yan-juan,YANG Yi-ping,CAO Yang,QING Hai-yun.Research Advance of Kiss-1 Gene Restraining Tumour from Metastasis[J].Journal of Guangxi Academy of Sciences,2008,24(1):45-48. [点击复制]
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| 摘要: |
| 肿瘤转移抑制基因Kiss-1广泛存在于人体各种组织,其编码的蛋白质Kisspeptins与人类孤儿G蛋白偶联受体结合后,不仅可以使细胞发生局灶性粘附进而使其运动能力受抑制,而且可以抑制MMP-9的表达以维持基底膜的完整,从而达到抑制肿瘤细胞侵袭和转移的作用。Kiss-1基因在肿瘤侵袭和转移过程中的作用目前尚未完全清楚,还有待于进一步研究证实。 |
| 关键词: Kiss-1基因 抑制 肿瘤 |
| DOI： |
| 投稿时间：2007-07-12修订日期：2007-08-28 |
| 基金项目:广西壮族自治区卫生厅课题(No.Z2006082)资助。 |
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| Research Advance of Kiss-1 Gene Restraining Tumour from Metastasis |
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XU Yan-juan, YANG Yi-ping, CAO Yang, QING Hai-yun
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| (Department of Pathology, the Oral Hospital Affiliated to Guangxi Medical University, Nanning, Guangxi, 530021, China) |
| Abstract: |
| Kiss-1 gene is a metastasis suppressor gene in various normal human tissues. Its kisspeptins binding with the human orphan G protein coupled receptor, not only make cells local adhesion, and in turn prevent tumour cells movement, but maintain the integrity of basement membrane by restraining the expression of MMP-9. Thereby kisspeptins can restrain tumuor cells from invasion and metastasis. As tumuor invasion and metastasis is a complicated process, in which the function of Kiss-1 gene is not clear now, a further study needs to be conducted on it. |
| Key words: Kiss-1 gene suppressor tumour |
