| 引用本文： |
-
雷明,欧夏莲,张羽,白镇瑜,李翠,冯世鑫,张占江.石杉碱甲生物合成研究进展[J].广西科学,2025,32(5):1026-1041. [点击复制]
- LEI Ming,OU Xialian,ZHANG Yu,BAI Zhenyu,LI Cui,FENG Shixin,ZHANG Zhanjiang.Research Progress in the Biosynthesis of Huperzine A[J].Guangxi Sciences,2025,32(5):1026-1041. [点击复制]
|
|
| |
|
|
| 本文已被：浏览 810次 下载 282次 |
码上扫一扫！ |
| 石杉碱甲生物合成研究进展 |
|
雷明1,2,3, 欧夏莲1,2,3, 张羽4, 白镇瑜5, 李翠1,2,3, 冯世鑫2, 张占江1,2,3
|
|
|
| (1.广西壮族自治区药用植物园, 广西药用资源保护与遗传改良重点实验室, 广西南宁 530023;2.广西壮族自治区药用植物园, 国家中医药传承创新中心, 广西南宁 530023;3.广西壮族自治区药用植物园, 广西壮族自治区中药资源智慧创制工程研究中心, 广西南宁 530023;4.中国科学院昆明动物研究所, 中国科学院天然活性多肽工程实验室/云南省活性多肽研究与利用重点实验室, 云南昆明 650201;5.广西医科大学基础医学院, 广西南宁 530000) |
|
| 摘要: |
| 石杉碱甲(Huperzine A,HupA)是从石杉科(Huperziaceae)植物及其内生真菌中分离提取到的一种生物碱，临床上主要用于阿尔茨海默病(Alzheimer's Disease,AD)、精神分裂症、重症肌无力等病证的缓解和治疗。本文描述了产HupA植物的组织培养和内生真菌的相关研究，介绍了HupA的化学合成研究进展，重点综述了HupA的生物来源、合成通路与功能基因的研究进展，并对未来利用微生物或异源植物等底盘细胞工业化量产HupA的关键技术突破口进行了探讨，旨在基于HupA的胆碱酯酶抑制特性及其生物合成通路，为神经退行性疾病的治疗、产HupA生物资源的合理利用及规模化生产提供参考。 |
| 关键词: 石杉碱甲 阿尔茨海默病 组织培养 内生真菌 生物合成通路 功能基因 |
| DOI：10.13656/j.cnki.gxkx.20251208.017 |
| 投稿时间：2025-08-07修订日期：2025-09-20 |
| 基金项目:广西科技基地与人才专项(AD22080016)，中央引导地方科技发展资金项目(桂科ZY24212031)，国家自然科学基金地区基金项目(32260107)和广西岐黄学者培养项目(GXQH202402)资助。 |
|
| Research Progress in the Biosynthesis of Huperzine A |
|
LEI Ming1,2,3, OU Xialian1,2,3, ZHANG Yu4, BAI Zhenyu5, LI Cui1,2,3, FENG Shixin2, ZHANG Zhanjiang1,2,3
|
| (1.Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, 530023, China;2.National Center for Traditional Chinese Medicine Inheritance and Innovation, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, 530023, China;3.Guangxi Engineering Research Center of Traditional Chinese Medicine Resource Intelligent Creation, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, 530023, China;4.Engineering Laboratory of Peptides of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan, 650201, China;5.School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, 530000, China) |
| Abstract: |
| Huperzine A (HupA) is an alkaloid extracted from plants of the Huperziaceae family and their endophytic fungi.Clinically,HupA is mainly used for the alleviation and treatment of diseases such as Alzheimer's Disease (AD),schizophrenia,and myasthenia gravis.This review provides a detailed description of the tissue culture of HupA-producing plants and related research on endophytic fungi,introduces the research progress in chemical synthesis of HupA,focuses on the research progress in the biological sources,pathways,and functional genes of HupA biosynthesis,and discusses the key technological breakthroughs for the industrial production of HupA by microbial or heterologous plant chassis cells in the future.The aim is to provide references for the treatment of neurodegenerative diseases,the rational utilization of HupA-producing biological resources,and the expansion of production based on the cholinesterase inhibitory properties and biosynthetic pathway of HupA. |
| Key words: Huperzine A Alzheimer's disease tissue culture endophytic fungi biosynthetic pathway functional genes |
|
|
|
|
|
