| 引用本文： |
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祁艳华,覃启剑,汪斌,金城,房文霞.酵母耐高温分子机制的研究进展[J].广西科学,2022,29(1):13-22,33. [点击复制]
- QI Yanhua,QIN Qijian,WANG Bin,JIN Cheng,FANG Wenxia.Research Progress on Molecular Mechanism of Thermo-tolerance in Yeast[J].Guangxi Sciences,2022,29(1):13-22,33. [点击复制]
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| 摘要: |
| 耐高温是酵母在工业生产中的重要特性之一。近年来，人们对耐高温酵母的应用研究日益重视并取得较大的进展，但其耐高温分子机制尚未明确。目前的研究结果表明，酵母耐高温机制涉及代谢网络调控、信号转导途径及多基因/蛋白共同作用等方面。本文从代谢途径、基因表达、酶活特性和蛋白质相互作用等4个方面综述当前酵母耐高温分子机制的研究进展，为酵母耐热性能的基因工程定向改造提供理论依据。 |
| 关键词: 酵母 耐高温 代谢途径 基因表达 热激蛋白 |
| DOI：10.13656/j.cnki.gxkx.20220313.004 |
| 投稿时间：2021-10-18 |
| 基金项目:广西科学院基本科研业务费(2021YBJ706)资助。 |
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| Research Progress on Molecular Mechanism of Thermo-tolerance in Yeast |
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QI Yanhua, QIN Qijian, WANG Bin, JIN Cheng, FANG Wenxia
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| (National Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China) |
| Abstract: |
| Thermo-tolerance is one of the important characteristics of yeast in industrial production.In recent years, more and more attentions have been paid to the application of thermo-tolerant yeast and great progress has been made, but the molecular mechanism of thermo-tolerance has not been clearly explained.The current research results indicated that the mechanism of yeast thermo-tolerance involved metabolic network regulation, signal transduction pathway and the interaction of multiple genes/proteins.In this article, the current research progress on molecular mechanisms of thermo-tolerance in yeast is reviewed from four aspects, including metabolic pathways, gene expression, characteristics of enzyme activity and protein interactions, which will provide a theoretical basis for rational design and improvement of yeast heat resistance and reduction of industrial production cost. |
| Key words: yeast thermo-tolerance metabolic pathway gene expression heat shock protein |
