| 引用本文： |
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潘东进,李嘉英,梁莉芬,姚绍嫦,梁方方,唐振洲.岩藻黄素降脂活性及其作用机制研究进展[J].广西科学,2021,28(6):588-598. [点击复制]
- PAN Dongjin,LI Jiaying,LIANG Lifen,YAO Shaochang,LIANG Fangfang,TANG Zhenzhou.Research Progress on Lipid Lowering Activity and Mechanism of Fucoxanthin[J].Guangxi Sciences,2021,28(6):588-598. [点击复制]
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| 摘要: |
| 岩藻黄素（Fucoxanthin）是海洋褐藻中主要的叶黄素类类胡萝卜素，也是褐藻中主要的降脂活性成分之一。岩藻黄素具有抗肿瘤、抗炎症、抗肥胖等多种生物活性，在代谢调节方面，岩藻黄素能促进脂肪分解和脂肪酸氧化，上调白色脂肪组织中线粒体解偶联蛋白1（UCP1）的表达，具有显著的抗肥胖功效，但其具体作用机制还需要进一步研究。本文综述近年来岩藻黄素在促进前体脂肪细胞分化、诱导白色脂肪细胞棕色化、调节胆固醇代谢等方面作用机制的研究成果，为进一步研究岩藻黄素的降脂作用机制提供理论参考。 |
| 关键词: 岩藻黄素 类胡萝卜素 抗肥胖 生物活性 作用机制 |
| DOI：10.13656/j.cnki.gxkx.20220118.001 |
| 投稿时间：2021-09-18 |
| 基金项目:广西中医药大学校级课题（2018BS041，2018BS037，2020MS009，2018ZD005-A14），广西高校中青年教师科研基础能力提升项目（2020KY07043）和国家级大学生创新创业训练计划项目（201910600013）资助。 |
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| Research Progress on Lipid Lowering Activity and Mechanism of Fucoxanthin |
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PAN Dongjin1, LI Jiaying1, LIANG Lifen1, YAO Shaochang2, LIANG Fangfang1, TANG Zhenzhou1
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| (1.Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, Guangxi, 530200, China;2.College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, 530200, China) |
| Abstract: |
| Fucoxanthin is the main lutein carotenoid and one of the main lipid-lowering active components in brown algae,which has many biological activities such as anti-tumor,anti-inflammation and anti-obesity.In terms of metabolic regulation,fucoxanthin can promote fat decomposition,fat acid oxidation and up-regulate the expression of mitochondrial uncoupling protein (UCP1) in white fat tissue,and has a significant anti-obesity effect.However,its specific mechanism needs further study.In this paper,the research results on the mechanism of fucoxanthin in promoting the differentiation of pre-adipocytes,inducing the browning of white adipocytes,and regulating cholesterol metabolism in recent years were summarized,so as to provide theoretical reference for further research on lipid-lowering mechanism of fucoxanthin. |
| Key words: fucoxanthin carotenoid anti-obesity bioactivity mechanism of action |
