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林漫漫,常静,张朋,刘生,王巧贞,黄庶识.激光拉曼光谱技术在生物活体研究中的应用进展[J].广西科学,2021,28(6):557-567. [点击复制]
- LIN Manman,CHANG Jing,ZHANG Peng,LIU Sheng,WANG Qiaozhen,HUANG Shushi.The Application Progress of Laser Raman Spectroscopy in the Study of Organisms in Vivo[J].Guangxi Sciences,2021,28(6):557-567. [点击复制]
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| 激光拉曼光谱技术在生物活体研究中的应用进展 |
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林漫漫1, 常静1, 张朋1, 刘生1, 王巧贞2, 黄庶识2
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| (1.中原工学院电子信息学院, 河南郑州 450007;2.广西科学院, 广西海洋天然产物与组合生物合成化学重点实验室, 广西南宁 530007) |
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| 摘要: |
| 激光拉曼光谱技术能够实现物质的分子级探测并给出具有高度特异性的“指纹图谱”，具有快速、无创、灵敏度高等优势，在生物医学研究尤其是生物活体研究领域展现出良好的应用潜力，是当前的研究热点之一。生物活体研究能够在不影响生物机体正常生理环境的情况下获取最真实的反馈信息，具有无创性，是生物医学研究最理想的手段。本文从生物组织、血液这两个方面来阐述激光拉曼光谱技术在生物活体研究中的现状及进展，并对其未来的发展前景进行展望。 |
| 关键词: 激光拉曼光谱 无创 生物活体 生物组织 血液 |
| DOI：10.13656/j.cnki.gxkx.20211229.001 |
| 投稿时间：2021-09-16 |
| 基金项目:国家自然科学基金项目（61874072）和河南省教育厅重点科研项目（18A510022）资助。 |
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| The Application Progress of Laser Raman Spectroscopy in the Study of Organisms in Vivo |
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LIN Manman1, CHANG Jing1, ZHANG Peng1, LIU Sheng1, WANG Qiaozhen2, HUANG Shushi2
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| (1.School of Electronic and Information Engineer, Zhongyuan University of Technology, Zhengzhou, Henan, 450007, China;2.Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynethesis Chemistry, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China) |
| Abstract: |
| Laser Raman spectroscopy can realize the molecular detection of substances and give a highly specific "fingerprint" spectrum.The optical detection technology has the advantages of rapid,non-invasive and high sensitivity,which has shown a good application potential in biomedical research,especially in the field of organisms in vivo. It is one of the current research hotspots.The biological research in vivo can obtain the most real feedback information without affecting the normal physiological environment of the organism.It is non-invasion and the most ideal means of biomedical research.In this paper,the status and progress of laser Raman spectroscopy technology in the study of organisms in vivo are expounded from two aspects of biological tissues and blood,and the prospect of its future development is prospected. |
| Key words: laser Raman spectroscopy non-invasion organisms in vivo biological tissue blood |
