| 引用本文： |
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黄云,李学坚,胡文姬,刘布鸣,邱宏聪.星点设计-效应面法优化双苷清咽含片处方的研究[J].广西科学,2019,26(5):588-593. [点击复制]
- HUANG Yun,LI Xuejian,HU Wenji,LIU Buming,QIU Hongcong.Prescription optimization of Shuangganqingyan tablet by central composite design-response surface methodology[J].Guangxi Sciences,2019,26(5):588-593. [点击复制]
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| 摘要: |
| 研究芒果苷、罗汉果甜苷和薄荷脑对双苷清咽含片抗炎药效的贡献，优选出该含片的最优处方。以小鼠腹腔通透性和二甲苯致小鼠耳廓肿胀度为指标，采用星点设计-效应面优化法，研究芒果苷、罗汉果甜苷和薄荷脑的用量对双苷清咽含片抗炎药效的影响。结果表明，对抗炎药效影响的主次顺序为芒果苷 > 罗汉果甜苷 > 薄荷脑；星点设计-效应面法优化法给出的优化处方范围为芒果苷占素片片重8.50%～17.50%；罗汉果甜苷占6.37%～13.13%，薄荷脑占0.18%～0.42%；最优处方为芒果苷占素片片重13.00%，罗汉果甜苷占9.75%，薄荷脑占0.30%。应用星点设计-效应面优化法可快速准确地给出双苷清咽含片的最优处方；双苷清咽含片的抗炎药效主要取决于芒果苷和罗汉果甜苷的用量，薄荷脑的用量无显著影响。 |
| 关键词: 双苷清咽含片 抗炎作用 星点设计-效应面优化法 处方优化 |
| DOI：10.13656/j.cnki.gxkx.20191024.006 |
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| 基金项目:广西中药质量标准研究重点实验室开放课题基金项目（GXGZZK201102和桂中重开201507）资助。 |
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| Prescription optimization of Shuangganqingyan tablet by central composite design-response surface methodology |
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HUANG Yun1, LI Xuejian1, HU Wenji2, LIU Buming3, QIU Hongcong3
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| (1.Guangxi Scientific Research Center of Chinese Medicine, Nanning, Guangxi, 530200, China;2.Wuhan Hospital of Traditional Chinese Medicine, Wuhan, Hubei, 430014, China;3.Guangxi Quality Standard of Chinese Medicine Research Laboratory, Nanning, Guangxi, 530022, China) |
| Abstract: |
| To study the contribution of mangiferin,mogroside and menthol to the anti-inflammatory effects of Shuangganqingyan tablet (SGQY tablet),it is preferred to prescribe the optimal formulation of this tablet.Mouse auricle tumefaction and abdominal capillary permeability were determined,and central composite design-response surface methodology (CCD-RSM) optimization tests were utilized to study the dosages of mangiferin,mogroside and menthol on the anti-inflammatory effects of SGQY tablet.The results showed that the main order of anti-inflammatory effects was mangiferin > mogroside > menthol.The optimized prescription range given by central composite design-response surface methodology method was that mangiferin accounted for 8.50% to 17.50% of the tablet weight,mogrosides accounted for 6.37%-13.13%,and menthol accounted for 0.18%-0.42%.The optimal prescription was that mogroside occupied accounted for 13.00% of the tablet weight,mogrosides accounted for 9.75%,and menthol accounted for 0.30%.The application of CCD-RSM method can quickly and accurately give the optimal prescription of SGQY tablet.The anti-inflammatory effect of SGQY tablet depends mainly on the amount of mangiferin and mogroside,the amount of menthol used has no significant effect. |
| Key words: Shuangganqingyan tablet (SGQY tablet) anti-inflammatory effects central composite design-response surface methodology (CCD-RSM) prescription optimization |
