| 引用本文： |
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李智明,邓鸣,卢日刚.ICP-MS分析复方甘草口服溶液中15种元素[J].广西科学,2019,26(5):527-531,538. [点击复制]
- LI Zhiming,DENG Ming,LU Rigang.Analysis of 15 elements in compound licorice oral solution by ICP-MS[J].Guangxi Sciences,2019,26(5):527-531,538. [点击复制]
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| 摘要: |
| 建立电感耦合等离子体质谱（ICP-MS）法测定复方甘草口服溶液中15种元素（Cr、Mn、Co、Ni、Cu、Zn、As、Cd、Sn、Sb、Ba、Hg、Pb、Al、Fe）。样品经微波消解后，根据待测元素的质量数选择相应元素作为内标，采用碰撞模式（氦模式）进行测定。结果显示，15种元素线性关系良好，相关系数均大于0.999，各元素的检出限在0.08～38.00 ng·mL-1，回收率在88.57%～107.10%（n=6）。该方法操作简便，分析速度快，灵敏度高，线性范围宽，可同时测定多种元素，适用于复方甘草口服溶液中元素的测定。 |
| 关键词: 复方甘草口服溶液 电感耦合等离子体质谱 元素 微波消解 重金属 限量 |
| DOI：10.13656/j.cnki.gxkx.20191106.001 |
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| 基金项目:广西壮族自治区药品监督管理局2019年广西药品安全科学技术研究项目（桂药科2019-（直属））资助。 |
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| Analysis of 15 elements in compound licorice oral solution by ICP-MS |
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LI Zhiming, DENG Ming, LU Rigang
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| (Guangxi Institute for Food and Drug Control, Nanning, Guangxi, 530021, China) |
| Abstract: |
| An inductively coupled plasma mass spectrometry (ICP-MS) method was established to determine 15 elements (Cr,Mn,Co,Ni,Cu,Zn,As,Cd,Sn,Sb,Ba,Hg,Pb,Al,Fe) in compound licorice oral solution.The compound licorice oral solution sample was digested by microwave,the corresponding element was selected as an internal standard according to the mass of the element to be tested,and the collision mode (helium mode) was used for measurement. The result showed that the linear relationship of the detected 15 elements was good,and the correlation coefficients were all greater than 0.999.The detection limit of each element was between 0.08 ng·mL-1 and 38.00 ng·mL-1,and the recovery rate was between 88.57% and 107.10% (n=6).The method has the advantages of simple operation,high analysis speed,high sensitivity,wide linear range,and simultaneous determination of various elements,and is suitable for the determination of elements in the compound licorice oral solution. |
| Key words: compound licorice oral solution ICP-MS element microwave digestion heavy metal limit |
