| 引用本文： |
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张欧,刘梦雪,刘永东,钟儒刚.Cu2+和Zn2+对模拟胃液中NDMA形成的影响[J].广西科学,2016,23(1):67-71. [点击复制]
- ZHANG Ou,LIU Mengxue,LIU Yongdong,ZHONG Rugang.Studies on the Effect of Cu2+ and Zn2+ on Carcinogenic NDMA Formation in Simulated Gastric Fluid[J].Guangxi Sciences,2016,23(1):67-71. [点击复制]
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| 摘要: |
| [目的]在模拟胃液条件下研究重金属Cu2+和Zn2+对内源致癌性N-二甲基亚硝胺(NDMA)形成的影响,并进一步探讨其作用机理。[方法]分别用气相色谱-质谱联用法(GC-MS)和离子色谱法(IC)来测定NDMA、二甲胺(DMA)和亚硝酸根(NO2-)含量。[结果]在模拟胃液条件下,Cu2+和Zn2+浓度高于50mg/L时,可以促进NDMA的形成,且当浓度由50mg/L增大到200mg/L时,Cu2+促进率由1.16%增大到94.56%,Zn2+促进率由21.32%增大到45.86%。在重金属浓度为符合或接近符合水质基准值1.0mg/L时,Cu2+和Zn2+对NDMA的形成也分别有16.88%和13.42%的促进率;而当重金属浓度为10mg/L时,两种离子却均抑制NDMA的形成。机理研究表明Cu2+、Zn2+促进NDMA的形成主要是由于其与DMA发生相互作用,进而导致NDMA形成。[结论]高浓度的Cu2+和Zn2+通过与DMA相互作用,形成活性中间体从而促进NDMA的生成。 |
| 关键词: 模拟胃液 重金属离子 NDMA 促进率 中间体 |
| DOI：10.13656/j.cnki.gxkx.2016.01.006 |
| 投稿时间：2015-12-01修订日期：2016-02-03 |
| 基金项目:北京市自然科学基金项目(8132015)资助。 |
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| Studies on the Effect of Cu2+ and Zn2+ on Carcinogenic NDMA Formation in Simulated Gastric Fluid |
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ZHANG Ou, LIU Mengxue, LIU Yongdong, ZHONG Rugang
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| (College of Life Science & Bioengineering, Beijing University of Technology, Beijing, 100124, China) |
| Abstract: |
| [Objective] The aim of this study was to investigate the effect of heavy metal irons Cu2+ and Zn2+ on the formation of N-nitrosodimethylamine (NDMA)in simulated gastric fluid (SGF)and further explore its mechanism.[Methods] The concentrations of NDMA and dimethylamine (DMA), nitrite (NO2-)were determined by gas chromatography-mass spectrometry (GC-MS)and ion chromatography (IC), respectively.[Results] Cu2+ and Zn2+ could promote the formation of NDMA when the concentrations of Cu2+ and Zn2+ were higher than 50mg/L in simulated gastric fluid (SGF).Meanwhile, the promotion rates were increased from 1.16%to 94.56% and 21.32% to 45.86% for Cu2+ and Zn2+, respectively, with their concentrations increasing from 50mg/L to 200mg/L.It is noteworthy that very low concentration of Cu2+ and Zn2+ at 1.0mg/L, which already or almost met their guideline values in drinking water, could still enhance NDMA formation with the promotion rates of 16.88% and 13.42%, respectively.Interestingly, both Cu2+ and Zn2+ could inhibit NDMA formation when their concentration was 10 mg/L.Mechanism research showed that the promotion of the NDMA was mainly due to the interaction between the heavy metal ions and DMA.[Conclusion] Heavy metal ions Cu2+ and Zn2+ at relatively high concentrations can both promote NDMA formation in SGF through interacting with DMA. |
| Key words: SGF heavy metal ions NDMA promotion rate intermediate |
