| 引用本文： |
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苏恒海,孙会静,李丽,周静.翠云草总生物碱对小鼠S180实体瘤的抑制作用[J].广西科学,2015,22(6):646-650. [点击复制]
- SU Heng-hai,SUN Hui-jing,LI Li,ZHOU Jing.Inhibition Effect of Total Alkaloid of Selaginella uncinata (Desv.) Spring on S180 Solid Tumor in Mice[J].Guangxi Sciences,2015,22(6):646-650. [点击复制]
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| 摘要: |
| [目的]研究翠云草Selaginella uncinata(Desv.) Spring总生物碱(TAS)对小鼠腋下S180实体瘤的抑制作用及抗肿瘤机制。[方法]分析空白对照组、5-FU阳性药对照组、TAS大和中剂量(300 mg·kg-1、150 mg·kg-1)组S180实体瘤重抑制率、NF-κB及COX-2的表达量,并观察各组切片。[结果]TAS对S180实体瘤具有抑制作用。TAS大、中剂量(300 mg·kg-1、150 mg·kg-1)组的瘤重、NF-κB和COX-2的表达量均显著低于空白对照组(P<0.05或P<0.01)。[结论]TAS能明显抑制S180实体瘤的生长,其抗肿瘤机制可能是通过抑制NF-κB和COX-2的表达,继而抑制向肿瘤输送养份和氧气的血管的生长,从而实现抗肿瘤作用。 |
| 关键词: 翠云草 总生物碱 抗肿瘤 作用机制 |
| DOI： |
| 投稿时间：2015-07-10 |
| 基金项目:广西自然科学基金项目(2012GXNSFAA053147),广西中药质量标准研究重点实验室开放课题基金项目(桂中重开201105)和广西"百人计划"项目(J13168)资助。 |
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| Inhibition Effect of Total Alkaloid of Selaginella uncinata (Desv.) Spring on S180 Solid Tumor in Mice |
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SU Heng-hai1,2, SUN Hui-jing1,2, LI Li1, ZHOU Jing1
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| (1.Guangxi University of Chinese Medicine, Nanning, Guangxi, 530222, China;2.The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China) |
| Abstract: |
| [Objective] The total alkaloid of Selaginella uncinata (Desv.) Spring(TAS) was extracted, and then its inhibition effect on S180 solid tumor in mice and the antitumor mechanism were studied.[Methods] The weight inhibition rate against S180 solid tumor, the expression of NF-κB and COX-2 were analyzed in the blank control group, 5-FU positive control group, and TAS large and middle dose groups (300 mg·kg-1 and 150 mg·kg-1 body weight), combined with observation of the sections from different groups.[Results] All the tumor weigh and the NF-κB/COX-2 concentration in the TAS high- and mid-dose groups(300 mg·kg-1 and 150 mg·kg-1) were statistically less than those in the control group(P<0.05 or P<0.01).[Conclusion] TAS can curb or suppress tumor growth.Its antitumor mechanism is probably to inhibit the expression of NF-κB/COX-2, thereby to inhibit the growth of the blood vessel around the tumor, by which tumor growth is curbed or suppressed. |
| Key words: Selaginella uncinata (Desv.) Spring total alkaloid anti-tumor mechanism |
