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吴尤娇,黄敏桃,黄云峰,赖茂祥,黄庶识,刘华钢.毛郁金乙醇提取物降血脂作用研究[J].广西科学,2015,22(2):130-134. [点击复制]
- WU You-jiao,HUANG Min-tao,HUANG Yun-feng,LAI Mao-xiang,HUANG Shu-shi,LIU Hua-gang.Antihyperliposis Effects of Ethanol Extract from Curcuma aromatica[J].Guangxi Sciences,2015,22(2):130-134. [点击复制]
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| 毛郁金乙醇提取物降血脂作用研究 |
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吴尤娇1,2, 黄敏桃3, 黄云峰4, 赖茂祥4, 黄庶识2, 刘华钢5
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| (1.广西中医药大学药学院, 广西南宁 530001;2.广西科学院生物物理实验室, 广西南宁 530007;3.广西生态工程职业技术学院, 广西柳州 545004;4.广西中医药研究院, 广西南宁 530022;5.广西医科大学, 广西南宁 530021) |
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| 摘要: |
| [目的]研究毛郁金(Curcuma aromatica)乙醇提取物降血脂作用,为其综合开发利用提供依据。[方法]通过高脂饲料喂养及脂肪乳剂灌胃,建立高脂血症大鼠模型,连续3周给予毛郁金乙醇提取物进行治疗,设正常组、高脂模型组、辛伐他汀组和毛郁金乙醇提取物高、中、低剂量(生药18 g·kg-1·d-1,12 g·kg-1·d-1,6 g·kg-1·d-1)组,以动物实验研究毛郁金乙醇提取物降血脂的作用。[结果]毛郁金乙醇提取物可降低大鼠血清总胆固醇(CHOL)、三酰甘油(TG)和低密度脂蛋白(LDL-C)的含量,并提高血清高密度脂蛋白(HDL-C)含量,对血清CHOL、LDL-C的降低作用:高 > 中 > 低剂量组,中剂量组对降低TG、升高HDL-C含量具有较好作用,毛郁金各给药组均对大鼠血清LDL-C含量有极显著降低作用。[结论]毛郁金乙醇提取物具有明显的降血脂作用。 |
| 关键词: 毛郁金 乙醇提取物 大鼠 降血脂 |
| DOI：10.13656/j.cnki.gxkx.20150508.001 |
| 投稿时间：2014-10-14修订日期：2014-11-20 |
| 基金项目:国家科技支撑计划项目(2011BAI01B04),广西科学研究与技术开发计划项目(0992003A-20)和广西自然科学基金项目(2010GXNSFD013044)资助。 |
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| Antihyperliposis Effects of Ethanol Extract from Curcuma aromatica |
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WU You-jiao1,2, HUANG Min-tao3, HUANG Yun-feng4, LAI Mao-xiang4, HUANG Shu-shi2, LIU Hua-gang5
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| (1.College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, 530001, China;2.Biophysics Laboratory, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China;3.Guangxi Eco-engineering Vocational and Technical College, Liuzhou, Guangxi, 545004, China;4.Guangxi Academy of Traditional Chinese Medicine, Nanning, Guangxi, 530022, China;5.Guangxi Medical University, Nanning, Guangxi, 530021, China) |
| Abstract: |
| [Objective] The antihyperliposis function of the ethanol extract from Curcuma aromatica was studied on rats in order to provide the basis for its comprehensive development and utilization.[Methods] High lipid rat model was prepared by feeding a high-fat diet and gastric perfusion of intralipid, then delivered with different doses of the ethanol extract from Curcuma aromatica.All experimental rats were divided into 6 groups:A normal control group, a high lipid model group, a positive group(Simvastatin) and three groups of ethanol extract from Curcuma aromatica with the equivalent weight of 18 g crude drug·kg-1·d-1, 12 g crude drug·kg-1·d-1and 6 g crude drug·kg-1·d-1, respectively.[Results] The ethanol extract from Curcuma aromatica could decrease the value of total cholesterol(CHOL), triglyceride (TG) and the low density lipoprotein-cholesterol (LDL-C) in the blood of rats, and also increase the value of high density lipoprotein-cholesterol (HDL-C).The CHOL and LDL-C decreasing effects ranked as:high > middle > low dose group.The middle dose group has a better effect on TG decreasing and HDL-C increasing.All the dose groups of Curcuma aromatica have significantly lower levels of LDL-C(P<0.01).[Conclusion] The ethanol extract from Curcuma aromatica shows clear effects on antihyperliposis. |
| Key words: Curcuma aromatica ethanol extract rat antihyperliposis |
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