| 引用本文： |
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班建东,蓝秀万,舒雨雁,汤圣希.眼镜蛇神经毒素低分子量水解物的镇痛研究[J].广西科学,1999,6(3):205-207,212. [点击复制]
- Ban Jiandong,Lan Xiuwan,Shu Yuyan,Tang Shengxi.The Analgesic Action of Low Molecular Catabolite from the α-Cobrotoxin of Chinese Cobra Venom[J].Guangxi Sciences,1999,6(3):205-207,212. [点击复制]
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| 摘要: |
| 眼镜蛇神经毒素(α-cobrotoxin或NT)经胃液水解后超滤得分子量<3000u低分子量α-cobrotoxin胃液水解物(α-cobrotoxin fragment,NTF)。该低分子量产物在小鼠热板及大鼠电尾嘶叫测痛实验,都显示出明显的镇痛作用,并有剂量-效应关系。NTF毒性比NT明显降低,NTF的镇痛显效时间比NT提前,维持时间长,不产生耐受现象。 |
| 关键词: 眼镜蛇 神经毒素 低分子量水解物 镇痛作用 吗啡 |
| DOI： |
| 投稿时间：1999-03-31修订日期：1999-05-25 |
| 基金项目: |
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| The Analgesic Action of Low Molecular Catabolite from the α-Cobrotoxin of Chinese Cobra Venom |
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Ban Jiandong, Lan Xiuwan, Shu Yuyan, Tang Shengxi
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| (Snake Venom Research Institute, Guangxi Medical Univ., 6 Binhulu, Nanning, Guangxi, 530021, China) |
| Abstract: |
| The α-cobrotoxin, NT, is the neurotoxin from the venom of Chinese cobra, Naja naja atra.The α-cobrotoxin fragment, NTF, is the catabolite by the human gastric juice in vitro and is ultrafiltrated to obtain the fragment of low molecular weight less than 3000 u. The analgesic action of NTF was tested by the hot-plate method for mice and the electric tail-stimulation method for rats.Both analgesic methods demonstrated analgesic action and had a dose-effect relationship. The analgesic start-time of NTF was quicker than the NT and the analgesic duration was longer than the NT.The toxicity of NTF was lower than that of NT by means of LD50 for mice. It was no drug tolerance in successive doses daily for NTF in rat. |
| Key words: Chinese cobra α-cobrotoxin low molecular catabolite analgesic action morphine |
