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杨定华,林伟雄,李绍森,卢全书,姜海行,卢榜裕,王文光,冯穗生,刘家奇,彭民浩.原发性肝癌P53基因第249密码子突变的研究[J].广西科学,1995,2(1):58-59. [点击复制]
- Yang Dinghua,Lin Weixiong,Li Shaosheng,Lu Quanshu,Jiang Haixing,Lu Bangyu,Wang Wenguang,Fong Shuisheng,Lin Jiaqi,Peng Minghao.The Mutation at Codon 249 of the P53 Gene in Primary Hepatocellular Carcinoma[J].Guangxi Sciences,1995,2(1):58-59. [点击复制]
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| 原发性肝癌P53基因第249密码子突变的研究 |
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杨定华, 林伟雄, 李绍森, 卢全书, 姜海行, 卢榜裕, 王文光, 冯穗生, 刘家奇, 彭民浩
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| (广西医科大学第一附属医院, 南宁市滨湖路6号 530021) |
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| 摘要: |
| 用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术对7例原发性肝细胞癌(PHC)进行P53基因第249密码子突变的检测。结果:7例肝细胞癌中3例有P53基因第249密码子突变,突变率达42.9%。 |
| 关键词: 肝细胞癌 P53基因 PCR-RFLP |
| DOI： |
| 投稿时间：1994-12-24 |
| 基金项目: |
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| The Mutation at Codon 249 of the P53 Gene in Primary Hepatocellular Carcinoma |
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Yang Dinghua, Lin Weixiong, Li Shaosheng, Lu Quanshu, Jiang Haixing, Lu Bangyu, Wang Wenguang, Fong Shuisheng, Lin Jiaqi, Peng Minghao
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| (Dept. of Surgery, First Affilliated Hospital, Guangxi Medical University, Nanning, 530021) |
| Abstract: |
| Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to examine the mutation at cod on 249 of the P53 gene in 7 cases of primary hepatocellular carcinoma. The mutation at cod on 249 of the P53 gene occurred in 3 out of the 7 cases. The mutant rate was 42.9%. |
| Key words: Hepatocellular Carcinoma P53 gene PCR-RFLP |
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