| 引用本文： |
-
邓卓霖,马韵,罗虹.南宁地区肝细胞性肝癌中突变型p53蛋白表达[J].广西科学,1995,2(1):55-57. [点击复制]
- Deng Zhuolin,Ma Yun,Luo Hong.p53 Mutation Protein ExPrssion in Hepatocellular Carcinoma in Nanning District[J].Guangxi Sciences,1995,2(1):55-57. [点击复制]
|
|
| 摘要: |
| 用ABC免疫组织化学方法,对南宁地区居民中13例肝细胞性肝癌(HCC)的活检组织进行研究。发现其中8例有突变型p53蛋白呈强阳性表达,占HCC病例数64.3%。南宁地区某些县,如扶绥县是我国著名的HCC高发区,不但HBV感染率高,而且是全国少有的AFB1高污染区,后者的作用不能忽视。与江苏启东和南部非洲HCC高发区一样,估计也会出现p53基因突变热点。 |
| 关键词: p53蛋白 肝细胞性肝癌 黄曲霉毒素B1 |
| DOI： |
| 投稿时间：1994-12-08 |
| 基金项目: |
|
| p53 Mutation Protein ExPrssion in Hepatocellular Carcinoma in Nanning District |
|
Deng Zhuolin, Ma Yun, Luo Hong
|
| (Guangxi Medical University, 6 Binhu Road, Nanning, Guangxi, 530021) |
| Abstract: |
| Immunohistochemistry ABC method was used to study 13 biopsy casses of hepatocellular carcinoma (HCC) in Nanning prefectural district. Eight cases (64.3%) were found to have positive expression of p53 mutation protein. Fu-Sui and its surrounding counties in the district are notorious for their high HCC incidence in China, not only high in infection of hepatitis B Verus (HBV) but also high in contamination of aflatoxin B1 (AFB1), and both are putative risk factors of HCC. The AFB1 could injure the DNA and cause a mutational hot spot in the p53 gene. Thus its effect should not be neglected. |
| Key words: p53 Protein hepatocellular carcinoma aflatoxin |
