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黄薇,李力,古明华,林玉纯,韦政清,陈若泽,李洁,刘宝印.人乳头瘤病毒感染的宫颈癌组织的病理形态学观察[J].广西科学,1994,1(4):42-47. [点击复制]
- Huang Wei,Li Li,Gu Minghua,Lin Yuchun,Wei Zhengqing,Chen Ruoze,Li Jie,Liu Baoyin.The Pathomorphology Study on Cervical Carcinoma Infected by Human Papill omavirus[J].Guangxi Sciences,1994,1(4):42-47. [点击复制]
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| 人乳头瘤病毒感染的宫颈癌组织的病理形态学观察 |
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黄薇, 李力, 古明华, 林玉纯, 韦政清, 陈若泽, 李洁, 刘宝印
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| (广西医科大学附属肿瘤医院妇瘤科, 南宁市滨湖路6号 530021) |
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| 摘要: |
| 应用核酸杂交技术结合组织病理学的光镜和电镜观察、检测80例子宫颈癌、42例正常宫颈组织、33例宫颈非典型增生组织和10例宫颈尖锐湿疣组织中的HPVs基因组相关序列。结果表明:(1)42例正常宫颈组织DNA无一例检出HPV,而在宫颈癌组织、宫颈非典型增生组织和宫颈尖锐湿疣组织中,HPV检出率分别达43.75%、45.45%和80%;(2)宫颈癌组织中阳性35例,阳性率为43.75%;HPV型别分布主要为HPV16型(18例,51.43%)和HPVR型(8例,22.86%);(3)18例HPV16型和3例HPV11/6型均为鳞癌,8例HPVR型中有6例也为鳞癌。HPV16型的18例中有12例为低分化癌,HPVR型的8例中有5例也为低分化癌;(4)不同型别HPV感染的宫颈癌组织,其病理形态学特征有所不同。研究表明,广西地区相当部分宫颈癌的发生与HPV感染有关,其感染的宫颈癌组织具有一定的病理形态学特征。 |
| 关键词: 乳头瘤病毒感染 子宫颈肿瘤 核酸杂交技术 病理学 |
| DOI： |
| 投稿时间：1994-07-14 |
| 基金项目: |
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| The Pathomorphology Study on Cervical Carcinoma Infected by Human Papill omavirus |
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Huang Wei, Li Li, Gu Minghua, Lin Yuchun, Wei Zhengqing, Chen Ruoze, Li Jie, Liu Baoyin
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| (Department of Gynecology Oncology, Affiliated Tumour Hospital, Guangxi Medical University, 6 Binhu Road, Nanning, Guangxi, 530021) |
| Abstract: |
| Eighty biopst specimens of carcinoma of the uterine cervix, fourly-two the normal cervix,thrity-three the atypical hyperplasia and ten the condyloma acuminatum were assayed for HPV DNA related sequences using the southern blot hybridization technique combining observation of light microscopy and electron microscopy, The results showed that:(1) No HPV DNA had been found in the normal uterine cervix; HPV DNA were found to be 43.75%, 45.45% and 80% respectively in the cervical carcinoma, the atypical hyperplasia and the condyloma acuminatum; (2) The HPV DNA types were mostly HPV 16 (18 cases, 45.43%) and HPV R (8 cases, 22.86%); (3) All 18 cases of HPV16 and 3 cases of HPV 11/6 were found to be squamous cell carcinomas. Six of the eight cases with HPV R were also squamous cell carcinoma; (4) The Pathomorphologic features of the cervical cancernous tissues with different HPV types were different. The results also showed that the development of quite a few cervical carcinoma in Guangxi might be related to HPV infection. |
| Key words: papillomavirus infection cervix neoplasms nucleic acid hybridization technique pathomorphology |
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