| 引用本文： |
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曾雪瑜,彭树勋.褪黑激素对小鼠免疫功能的影响[J].广西科学,1994,1(3):41-42,79. [点击复制]
- Zeng Xueyu,Pang S. F..Effect of Melatonin on Immune Function in Mice[J].Guangxi Sciences,1994,1(3):41-42,79. [点击复制]
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| 摘要: |
| 采用3H-TdR掺入法和溶血素测定法观察褪黑激素(Mt)对刀豆素(ConA)诱导小鼠脾淋巴细胞增殖和半数溶血值(HC50)的影响。结果表明,Mt于光周期傍晚腹腔注射0.01、0.05、0.1mg/kg能明显促进ConA诱导的小鼠脾淋巴细胞增殖,提高可的松抑制的脾淋巴细胞增殖及环磷酰胺抑制的半数溶血值。提示Mt具有免疫增强作用和对抗应激引起的免疫抑制作用,在临床医学上具有广阔应用前景。 |
| 关键词: 褪黑激素 淋巴细胞增殖 半数溶血值(HC50) |
| DOI： |
| 投稿时间：1994-05-25修订日期：1994-08-11 |
| 基金项目: |
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| Effect of Melatonin on Immune Function in Mice |
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Zeng Xueyu, Pang S. F.
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| (Faculty of Medicine, University of Hong Kong, Sassoon Road, Hong Kong) |
| Abstract: |
| The effects of proliferative responses of melatonin (Mt) on splenocytes stimulated by Con A and HC50 value in mice are studied using 3H-TdR infiltration and hemelysin mensuration. The results show that in medium light (ML), Intraperitoneal (ip) 0.01,0.05, 0.1mg/kg Mt can significantly facilitate prolifera tive responses of splenocyted stimulated by con A in normal mice and, can enchance the proliferation of splenocytes inhibited by cortisone and HC50 value inhibited by cyclophosphamide. The results indicate that Mt possessed potential immunity and anti-tress function. |
| Key words: melatonin proliferation of splenocytes HC50 value |
